Evidence map›Paper›PMID 28781432›Full record

ArticleParticle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems2016

Mosaic Interdigitated Structure in Nanoparticle-Templated Phospholipid Bilayer Supports Partial Lipidation of Apolipoprotein A-I.

Wangqiang Sun, Weiqiang Wu, Kaylin M McMahon, Jonathan S Rink, C Shad Thaxton

Abstract read
In one paragraph

Article in Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wangqiang SunDepartment of Urology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611, United States; School of Materials Science & Engineering, Hubei University of Technology, Wuhan 430068, China; Simpson Querrey Institute for BioNanotechnology, Northwestern University, 303 East Superior, Chicago, Illinois 60611, United States; Hubei Provincial Key Laboratory of Green Materials for Light Industry, Hubei University of Technology, Wuhan 430068, China.
Weiqiang WuInstitute for Catalysis in Energy Processes and Center for Catalysis and Surface Science, Evanston, IL 60208, United States; Department of Chemistry, Northwestern University, Evanston, IL 60208, United States.
Kaylin M McMahonDepartment of Urology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611, United States; Simpson Querrey Institute for BioNanotechnology, Northwestern University, 303 East Superior, Chicago, Illinois 60611, United States.
Jonathan S RinkDepartment of Urology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611, United States; Simpson Querrey Institute for BioNanotechnology, Northwestern University, 303 East Superior, Chicago, Illinois 60611, United States.
C Shad ThaxtonDepartment of Urology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611, United States; Simpson Querrey Institute for BioNanotechnology, Northwestern University, 303 East Superior, Chicago, Illinois 60611, United States; International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 303 East Superior, Chicago, Illinois 60611, United States.

Funding

Theranostic Magnetic Nanostructures for the Molecular Imaging of CancerU54CA151880 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LIN, SIMON M. · 2010 to 2014
$11.5M
High Density Lipoprotein Nanoparticles for siRNA DeliveryR01CA167041 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI THAXTON, COLBY SHAD · 2012 to 2016
$1.6M
NCI NIH HHS R01 CA167041NCI NIH HHS U54 CA151880
6 · The paper itself

Abstract

Using gold nanoparticle-templated high-density lipoprotein-like particles as a model, the nanoparticle-templated phospholipid bilayer is studied from the bottom-up. Data support the phospholipids have a mosaic interdigitated structure. The discontinuous lipid milieu supports partial lipidation of apolipoprotein A-I, different from an ordinary phospholipid bilayer, suggesting that synergy between nanoparticle templates and bound phospholipid layers can modulate amphiphilic proteins for desired functions.

Indexed as

apolipoprotein A-Ibio-nanostructurehigh-density lipoproteinlipidationphospholipid

Identifiers

PMID28781432
PMCPMC5544021

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.