ArticleMolecular cell2017
Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis.
Article in Molecular cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- The next decade of SET: from an oncoprotein to beyond.Journal of molecular cell biology · 2024Review
- PP2A complex disruptor SET prompts widespread hypertranscription of growth-essential genes in the pancreatic cancer cells.Science advances · 2024Article
- Deciphering the Role of Shugoshin-Like Protein 1 in Lung Adenocarcinoma: A Comprehensive Analysis andFrontiers in oncology · 2022Article
- Article
- SET levels contribute to cohesion fatigue.Molecular biology of the cell · 2021Article
- The missing linkGenes & development · 2021Review
- Embryonic Stem Cell Differentiation Is Regulated by SET through Interactions with p53 and β-Catenin.Stem cell reports · 2020Article
- Functioning mechanisms of Shugoshin-1 in centromeric cohesion during mitosis.Essays in biochemistry · 2020Review
- Priming chromatin for segregation: functional roles of mitotic histone modifications.Cell cycle (Georgetown, Tex.) · 2020Review
- Aurora B kinase activity is regulated by SET/TAF1 on Sgo2 at the inner centromere.The Journal of cell biology · 2019Article
- SET binding to Sgo1 inhibits Sgo1-cohesin interactions and promotes chromosome segregation.The Journal of cell biology · 2019Article
- Cyclin-dependent kinase 1-mediated phosphorylation of SET at serine 7 is essential for its oncogenic activity.Cell death & disease · 2019Article
- CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation.The Journal of cell biology · 2019Article
- Protein phosphatases in the regulation of mitosis.The Journal of cell biology · 2019Review
- SGO1 induces proliferation and metastasis of prostate cancer through AKT-mediated signaling pathway.American journal of cancer research · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Precise control of sister chromatid separation during mitosis is pivotal to maintaining genomic integrity. Yet, the regulatory mechanisms involved are not well understood. Remarkably, we discovered that linker histone H1 phosphorylated at S/T18 decorated the inter-chromatid axial DNA on mitotic chromosomes. Sister chromatid resolution during mitosis required the eviction of such H1S/T18ph by the chaperone SET, with this process being independent of and most likely downstream of arm-cohesin dissociation. SET also directed the disassembly of Shugoshins in a polo-like kinase 1-augmented manner, aiding centromere resolution. SET ablation compromised mitotic fidelity as evidenced by unresolved sister chromatids with marked accumulation of H1S/T18ph and centromeric Shugoshin. Thus, chaperone-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression. Our findings also elucidate the functional implications of the decades-old observation of mitotic linker histone phosphorylation, serving as a paradigm to explore the role of linker histones in bio-signaling processes.
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Registered trials
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