ArticleBiomechanics and modeling in mechanobiology2018
A viscoelastic anisotropic hyperelastic constitutive model of the human cornea.
Article in Biomechanics and modeling in mechanobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Ex vivo, in vivo and in silico studies of corneal biomechanics: a systematic review.Physical and engineering sciences in medicine · 2024Pooled it
- Linear Viscoelasticity of Human Ocular Tissues During Tensile Stress Relaxation.Investigative ophthalmology & visual science · 2026Article
- Microstructure and In-Plane Mechanical Property Comparison of Human and Porcine Cornea.Journal of biomechanical engineering · 2025Article
- Corneal viscoelasticity is associated with intraocular pressure under physiological baseline: insights from the rheological properties of corneal lenticules.Frontiers in bioengineering and biotechnology · 2025Article
- Full-field noise-correlation elastography for in-plane mechanical anisotropy imaging.Biomedical optics express · 2024Article
- [Characterization of rabbit corneal biomechanical properties after corneal refractive surgery based on rapid loading-unloading uniaxial tensile test].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- Study of the Influence of Boundary Conditions on Corneal Deformation Based on the Finite Element Method of a Corneal Biomechanics Model.Biomimetics (Basel, Switzerland) · 2024Article
- Application of biomaterials and nanotechnology in corneal tissue engineering.The Journal of international medical research · 2023Review
- Article
- Novel Method of Measuring Corneal Viscoelasticity Using the Corvis ST Tonometer.Journal of clinical medicine · 2022Article
- Exploring the Biomechanical Properties of the Human CorneaFrontiers in bioengineering and biotechnology · 2021Article
- Microstructure-based numerical simulation of the mechanical behaviour of ocular tissue.Journal of the Royal Society, Interface · 2019Article
- Optical Coherence Elastography-Based Corneal Strain Imaging During Low-Amplitude Intraocular Pressure Modulation.Frontiers in bioengineering and biotechnology · 2019Article
- A modified formulation of quasi-linear viscoelasticity for transversely isotropic materials under finite deformation.Proceedings. Mathematical, physical, and engineering sciences · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A constitutive model based on the continuum mechanics theory has been developed which represents interlamellar cohesion, regional variation of collagen fibril density, 3D anisotropy and both age-related viscoelastic and hyperelastic stiffening behaviour of the human cornea. Experimental data gathered from a number of previous studies on 48 ex vivo human cornea (inflation and shear tests) enabled calibration of the constitutive model by numerical analysis. Wide-angle X-ray scattering and electron microscopy provided measured data which quantify microstructural arrangements associated with stiffness. The present study measures stiffness parallel to the lamellae of the cornea which approximately doubles with an increase in strain rate from 0.5 to 5%/min, while the underlying stromal matrix provides a stiffness 2-3 orders of magnitude lower than the lamellae. The model has been simultaneously calibrated to within 3% error across three age groups ranging from 50 to 95 years and three strain rates across the two loading scenarios. Age and strain-rate-dependent material coefficients allow numerical simulation under varying loading scenarios for an individual patient with material stiffness approximated by their age. This present study addresses a significant gap in numerical representation of the cornea and has great potential in daily clinical practice for the planning and optimisation of corrective procedures and in preclinical optimisation of diagnostic procedures.
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