ReviewDevelopment genes and evolution2017
The flexible stem hypothesis: evidence from genetic data.
Review in Development genes and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- Exposome variations affect Drosophila bristle patterning via the regulation of proneural genes through distinct mechanisms.Scientific reports · 2025Article
- A mechanistic basis for genetic assimilation in natural fly populations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Evolved and Plastic Gene Expression in Adaptation of a Specialist Fly to a Novel Niche.Molecular ecology · 2025Article
- Foraging-induced craniofacial plasticity is associated with an early, robust and dynamic transcriptional response.Proceedings. Biological sciences · 2024Article
- The H3K79me3 methyl-transferase Grappa is involved in the establishment and thermal plasticity of abdominal pigmentation in Drosophila melanogaster females.Scientific reports · 2024Article
- Speciation and repeated origins of hypertrophied lips in parallel adaptive radiations of cyprinid fish from East Africa.Ecology and evolution · 2023Article
- The transcriptional state and chromatin landscape of cichlid jaw shape variation across species and environments.Molecular ecology · 2023Article
- Evolved Transcriptional Responses and Their Trade-Offs after Long-Term Adaptation of Bemisia tabaci to a Marginally Suitable Host.Genome biology and evolution · 2022Article
- Linking Molecular Mechanisms and Evolutionary Consequences of Resource Polyphenism.Frontiers in integrative neuroscience · 2022Review
- Ciliary Rootlet Coiled-Coil 2 (crocc2) Is Associated with Evolutionary Divergence and Plasticity of Cichlid Jaw Shape.Molecular biology and evolution · 2021Article
- A morphological trait involved in reproductive isolation between Drosophila sister species is sensitive to temperature.Ecology and evolution · 2021Article
- Hedgehog signaling is necessary and sufficient to mediate craniofacial plasticity in teleosts.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Review
- Investigating the evolution and development of biological complexity under the framework of epigenetics.Evolution & development · 2019Article
- Genomics of Developmental Plasticity in Animals.Frontiers in genetics · 2019Review
- bric à brac (bab), a central player in the gene regulatory network that mediates thermal plasticity of pigmentation in Drosophila melanogaster.PLoS genetics · 2018Article
- Developmental Plasticity and Robustness of a Nematode Mouth-Form Polyphenism.Frontiers in genetics · 2018Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phenotypic plasticity, the ability of a given genotype to produce different phenotypes in response to distinct environmental conditions, is widely observed in the wild. It is believed to facilitate evolution and, under the "flexible stem hypothesis", it is thought that an ancestral plastic species can be at the origin of sister lineages with divergent phenotypes fixed by genetic assimilation of alternative morphs. We review here the genetic mechanisms underlying such phenomenon. We show several examples in which the same gene shows transcriptional plasticity in response to environmental factors and divergence of expression within or between species. Thus, the same gene is involved both in the plasticity of a trait and in the evolution of that trait. In a few cases, it can be traced down to cis-regulatory variation in this gene and, in one case, in the very same regulatory sequence whose activity is modulated by the environment. These data are compatible with the "flexible stem hypothesis" and also suggest that the evolution of the plasticity of a trait and the evolution of the trait are not completely uncoupled as they often involve the same locus. Furthermore, the "flexible stem hypothesis" implies that it is possible to canalize initially plastic phenotypes. Several studies have shown that it was possible through modification of chromatin regulation or hormonal signalling/response. Further studies of phenotypic plasticity in an evolutionary framework are needed to see how much the findings described in this review can be generalized.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.