Evidence map›Paper›PMID 28779950›Full record

ArticleClinical radiology2017

Value of the portal venous phase in evaluation of treated hepatocellular carcinoma following transcatheter arterial chemoembolisation.

A Lam, D Fernando, C C Sirlin, M Nayyar, S C Goodwin, D K Imagawa, C Lall

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04299919 (The Artificial Intelligent Prognostic Assessment and Pathological Basis Research of Early Primary Hepatocellular Carcinoma After Minimally Invasive Treatment Based on Multimodal MRI and Clinical Big Data), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04299919 unknown statusnot on this map

The Artificial Intelligent Prognostic Assessment and Pathological Basis Research of Early Primary Hepatocellular Carcinoma After Minimally Invasive Treatment Based on Multimodal MRI and Clinical Big Data

TypeobservationalSponsorThe First Affiliated Hospital of Dalian Medical UniversityRan2007 to 2024Enrolled1,200ConditionsHepatocellular CarcinomaArmsMinimally invasive treatment, Hepatectomy
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

A LamDepartment of Radiological Sciences, Irvine School of Medicine, University of California, 101 The City Drive South, Orange, CA 92868, USA. Electronic address: ahlam@uci.edu.
D FernandoDepartment of Radiological Sciences, Irvine School of Medicine, University of California, 101 The City Drive South, Orange, CA 92868, USA.
C C SirlinDepartment of Radiology, University of California, San Diego Medical Center, 200 West Arbor Drive, San Diego, CA 92103, USA.
M NayyarDepartment of Radiological Sciences, Irvine School of Medicine, University of California, 101 The City Drive South, Orange, CA 92868, USA.
S C GoodwinDepartment of Radiological Sciences, Irvine School of Medicine, University of California, 101 The City Drive South, Orange, CA 92868, USA.
D K ImagawaDepartment of Surgery, Irvine School of Medicine, University of California, 101 The City Drive South, Orange, CA 92868, USA.
C LallDepartment of Radiological Sciences, Irvine School of Medicine, University of California, 101 The City Drive South, Orange, CA 92868, USA.

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
NCATS NIH HHS UL1 TR001414
6 · The paper itself

Abstract

aimTo evaluate the utility of the portal venous phase on multiphasic computed tomography (CT) after treatment of hepatocellular carcinoma (HCC) with trans-arterial chemoembolisation (TACE). MATERIALS AND

methodsThis was a retrospective review of patients who underwent TACE for HCC between 1 April 2012 and 21 December 2014, with appropriate multiphasic, pre- and post-procedural CT examinations. The maximum non-contrast, arterial phase, and portal venous phase attenuation values of the tumour and tumour bed were evaluated within a region of interest (ROI), with values adjusted against background hepatic parenchyma. Linear regression analyses were performed for both the arterial and venous phases, to assess the level of enhancement and to determine if the venous phase had additional value in this setting.

resultsA total of 86 cases from 51 patients were reviewed. All pre-procedural CT examinations of lesions demonstrated arterial phase enhancement with portal venous and delayed phase washout compatible with HCC. The post-procedural CT examinations following TACE revealed expected decreased arterial enhancement. Sixty-five cases (76%) showed persistent non-enhancement on the portal venous phase following embolisation therapy. A total of 21 cases (24%), however, demonstrated progressive portal venous hyper enhancement. Linear regression analysis demonstrated a statistical significance between the difference in maximal arterial and portal venous enhancement in these cases.

conclusionFollowing TACE, the treated lesion may demonstrate portal venous phase hyper-enhancement within the tumour bed. As such, full attention should be given to these images for comprehensive evaluation of tumour response following treatment.

Indexed as

AdultAgedAged, 80 and overCarcinoma, HepatocellularChemoembolization, TherapeuticFemaleHumansLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedPortal VeinRetrospective StudiesTomography, X-Ray ComputedTreatment Outcome

Identifiers

PMID28779950
PMCPMC6091555

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.