Evidence map›Paper›PMID 28779468›Full record

ArticleInternational journal of behavioral medicine2017

Fasting Glucose and the Risk of Depressive Symptoms: Instrumental-Variable Regression in the Cardiovascular Risk in Young Finns Study.

Karolina Wesołowska, Marko Elovainio, Taina Hintsa, Markus Jokela, Laura Pulkki-Råback, Niina Pitkänen, Jari Lipsanen, Janne Tukiainen, Leo-Pekka Lyytikäinen, Terho Lehtimäki and 3 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in International journal of behavioral medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Karolina WesołowskaInstitute of Behavioral Sciences, University of Helsinki, P.O. Box 9, (Siltavuorenpenger 1 A), 00014, Helsinki, Finland. karolina.wesolowska@helsinki.fi.
Marko ElovainioInstitute of Behavioral Sciences, University of Helsinki, P.O. Box 9, (Siltavuorenpenger 1 A), 00014, Helsinki, Finland.
Taina HintsaInstitute of Behavioral Sciences, University of Helsinki, P.O. Box 9, (Siltavuorenpenger 1 A), 00014, Helsinki, Finland.
Markus JokelaInstitute of Behavioral Sciences, University of Helsinki, P.O. Box 9, (Siltavuorenpenger 1 A), 00014, Helsinki, Finland.
Laura Pulkki-RåbackInstitute of Behavioral Sciences and Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland.
Niina PitkänenResearch Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Jari LipsanenInstitute of Behavioral Sciences, University of Helsinki, P.O. Box 9, (Siltavuorenpenger 1 A), 00014, Helsinki, Finland.
Janne TukiainenVATT Institute for Economic Research, Helsinki, Finland.
Leo-Pekka LyytikäinenSchool of Medicine, University of Tampere, Tampere, Finland.
Terho LehtimäkiSchool of Medicine, University of Tampere, Tampere, Finland.
Markus JuonalaDepartment of Medicine, University of Turku, Turku, Finland.
Olli RaitakariResearch Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Liisa Keltikangas-JärvinenInstitute of Behavioral Sciences, University of Helsinki, P.O. Box 9, (Siltavuorenpenger 1 A), 00014, Helsinki, Finland.
University of Helsinki · FITampere University · FIMurdoch Children's Research Institute · AUTurku University Hospital · FIUniversity of Turku · FIVATT Institute for Economic Research · FI

Funding

Kuopio, Tampere, and Turku University Hospital Medical Funds X51001Suomen Akatemia 117787Suomen Akatemia 121584Suomen Akatemia 124282Suomen Akatemia 126925Suomen Akatemia 129378Suomen Akatemia 134309Suomen Akatemia 265869Suomen Akatemia 265977Suomen Akatemia 286284Suomen Akatemia 41071
6 · The paper itself

Abstract

purposeType 2 diabetes (T2D) has been associated with depressive symptoms, but the causal direction of this association and the underlying mechanisms, such as increased glucose levels, remain unclear. We used instrumental-variable regression with a genetic instrument (Mendelian randomization) to examine a causal role of increased glucose concentrations in the development of depressive symptoms.

methodData were from the population-based Cardiovascular Risk in Young Finns Study (n = 1217). Depressive symptoms were assessed in 2012 using a modified Beck Depression Inventory (BDI-I). Fasting glucose was measured concurrently with depressive symptoms. A genetic risk score for fasting glucose (with 35 single nucleotide polymorphisms) was used as an instrumental variable for glucose.

resultsGlucose was not associated with depressive symptoms in the standard linear regression (B = -0.04, 95% CI [-0.12, 0.04], p = .34), but the instrumental-variable regression showed an inverse association between glucose and depressive symptoms (B = -0.43, 95% CI [-0.79, -0.07], p = .020). The difference between the estimates of standard linear regression and instrumental-variable regression was significant (p = .026)

conclusionOur results suggest that the association between T2D and depressive symptoms is unlikely to be caused by increased glucose concentrations. It seems possible that T2D might be linked to depressive symptoms due to low glucose levels.

Indexed as

GlucoseAdolescentCardiovascular DiseasesChildChild, PreschoolCross-Sectional StudiesDepressionDiabetes Mellitus, Type 2FastingFemaleFinlandHumansMaleRisk FactorsGlucoseDepressive symptomsFasting glucoseHyperglycemiaInstrumental-variable regressionMendelian randomizationType 2 diabetes (T2D)

Identifiers

PMID28779468
OpenAlexW2744374077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.