ArticleInfection2017
Low antibodies titer and serological cross-reaction between Coxiella burnetii and Legionella pneumophila challenge the diagnosis of mediastinitis, an emerging Q fever clinical entity.
Article in Infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Epidemiological investigation of a clinical case of Q fever in the Brazilian Amazon.Parasite epidemiology and control · 2026Article
- VirCliaEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Comparison of in-house immunofluorescence assay (IFA) and commercial enzyme-linked immunosorbent assay (ELISA) for Coxiella burnetii infection in cattle.Veterinary research communications · 2025Article
- Diagnostic serology test comparison for Q fever and Rift Valley fever in humans and livestock from pastoral communities.PLoS neglected tropical diseases · 2024Article
- Review
- First serological evidence of Q fever in large ruminants and its associated risk factors in Punjab, Pakistan.Scientific reports · 2022Article
- Evaluation using latent class models of the diagnostic performances of three ELISA tests commercialized for the serological diagnosis of Coxiella burnetii infection in domestic ruminants.Veterinary research · 2021Article
- Infective endocarditis caused byIDCases · 2021Article
- Validation of a Novel Commercial ELISA Test for the Detection of Antibodies againstPathogens (Basel, Switzerland) · 2020Article
- Retrospective Study on the Occurrence of Antibodies againstPathogens (Basel, Switzerland) · 2020Article
- Case Report: Visceral Leishmaniasis Falsely Diagnosed as Q Fever.The American journal of tropical medicine and hygiene · 2020Article
- Evaluation of the Diagnostic Potential of RecombinantMicroorganisms · 2020Article
- Persistent Coxiella burnetii cardiovascular infection on Bentall-De Bono prosthesis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Review
- Hemodialysis vascular graft as a focus of persistent Q fever.Infection · 2018Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoxiella burnetii is an intracellular and fastidious bacterium responsible of acute and persistent Q fever infection. Endocarditis and vascular infections are the most common serious complications of acute Q fever. CASE REPORT: We report the case of a 63-year-old man that presented a mediastinitis associated with a prosthetic vascular infection. Serological cross-reaction was observed between Coxiella burnetii, the agent of Q fever, and Legionella pneumophila with higher antibodies titer for L. pneumophila (IgG = 1:512) than for C. burnetii (phase I IgG = 1:400). We performed western blot with cross-adsorption that supports the diagnosis of C. burnetii infection. Two weeks later, a positive qPCR and culture for C. burnetii on swab taken from the mediastinal cutaneous fistula confirmed the definitive microbiological diagnosis of Q fever mediastinitis.
conclusionCross-reactivity between C. burnetii and Legionella spp. has long been known and should be considered in patients with persistent infections. It is important to establish the definite diagnosis because the antibiotic treatment regimens and duration are significantly different. To the best of our knowledge, we reported here the first case of mediastinitis associated to C. burnetii and we diagnosed this persistent infection despite low anti-C. burnetii phase I IgG levels.
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