Evidence map›Paper›PMID 28779271›Full record

ArticleInternational ophthalmology2018

Choriocapillaris' alterations in the presence of reticular pseudodrusen compared to drusen: study based on OCTA findings.

Irini Chatziralli, George Theodossiadis, Dimitrios Panagiotidis, Paraskevi Pousoulidi, Panagiotis Theodossiadis

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in International ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 28 citations in OpenAlex.

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  10. The RAP study, report 4: morphological and topographical characteristics of multifocal macular neovascularization type 3.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
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  13. Observational
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  15. A novelOphthalmic genetics · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Irini Chatziralli2nd Department of Ophthalmology, University of Athens, 1, Rimini street, 12462, Haidari, Athens, Greece. eirchat@yahoo.gr.
George Theodossiadis2nd Department of Ophthalmology, University of Athens, 1, Rimini street, 12462, Haidari, Athens, Greece.
Dimitrios PanagiotidisMacula Center, Athens, Greece.
Paraskevi PousoulidiMacula Center, Athens, Greece.
Panagiotis Theodossiadis2nd Department of Ophthalmology, University of Athens, 1, Rimini street, 12462, Haidari, Athens, Greece.
National and Kapodistrian University of Athens · GRAthens Medical Center · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the qualitative changes of choriocapillaris in the presence of reticular pseudodrusen (RPD) and compare them with conventional small drusen due to dry age-related macular degeneration (AMD). PROCEDURES: Participants in this study were 59 patients with non-neovascular AMD, presenting either RPD (23 patients) or drusen (36 patients) of similar size. All patients underwent best-corrected visual acuity, slit-lamp examination, spectral domain optical coherence tomography (SD-OCT) and optical coherence tomography angiography.

resultsThe morphology of RPD in SD-OCT was depicted either as conical or as amorphous in shape. Both types were found to affect the ellipsoid zone. The presence of RPD was associated with choriocapillaris' reduced blood flow signal (non-perfusion), while the same but less intense choriocapillaris' non-perfusion appearance was noticed in the presence of drusen of the same size. In 13% of patients with RPD, ghost-like vessels were observed in the non-perfusion area of choriocapillaris, while in none patients with drusen ghost vessels were present. In all 23 patients with RPD, the choriocapillaris non-perfusion was correspondent to the location of RPD. Additionally, in about 35% of them, choriocapillaris' impairment was also observed, covering areas outside RPD.

conclusionsMorphological impairment of choriocapillaris was more intense in patients with RPD than in those with conventional drusen of the same size. The existence of ghost vessels in the area of choriocapillaris' density defect suggested that choriocapillaris' alterations may occur in patients with RPD.

Indexed as

AgedCapillariesChoroidCross-Sectional StudiesFemaleFluorescein AngiographyFundus OculiHumansMaleRetinal DrusenRetinal VesselsTomography, Optical CoherenceWet Macular DegenerationAge-related macular degenerationDrusenOptical coherence tomographyReticular pseudodrusen

Identifiers

PMID28779271
OpenAlexW2744722739

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.