ArticleNature communications2017
Onion-like multilayered polymer capsules synthesized by a bioinspired inside-out technique.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Nanoarchitectonics Approach for Hydrogel Surface Functionalization via Self-Assembly of Terminally Modified Cello-oligosaccharides.ACS polymers Au · 2026Article
- Advances in Cellulose-Based Hydrogels for Drug Delivery: Preparation, Modification and Challenges.Gels (Basel, Switzerland) · 2025Review
- Gel-Gel Interface Engineering for the Synthesis of Anisotropic Hydrogels with Designable Polymer Orientations.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Concentric ice-templating of ultracompressible tough hydrogels with bioinspired circumferentially aligned architecture.Science advances · 2025Article
- Capsule robots for the monitoring, diagnosis, and treatment of intestinal diseases.Materials today. Bio · 2024Review
- Biomimetic Electronic Skin through Hierarchical Polymer Structural Design.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Orthogonal Gelations to Synthesize Core-Shell Hydrogels Loaded with Nanoemulsion-Templated Drug Nanoparticles for Versatile Oral Drug Delivery.Advanced healthcare materials · 2023Article
- Self-healing and shape-shifting polymers controlled by dynamic bonds.Smart molecules : open access · 2023Review
- Hierarchical encapsulation of bacteria in functional hydrogel beads for inter- and intra- species communication.Acta biomaterialia · 2023Article
- Alginate microfibers as therapeutic delivery scaffolds and tissue mimics.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Application of encapsulated nano materials as feed additive in livestock and poultry: a review.Veterinary research communications · 2022Review
- The Biocomplex Assembled from Antigen Peptide and Toll-like Receptor Agonist Improved the Immunity against Pancreatic AdenocarcinomaJournal of oncology · 2022Article
- Research Progress in the Multilayer Hydrogels.Gels (Basel, Switzerland) · 2021Review
- Reaction-diffusion hydrogels from urease enzyme particles for patterned coatings.Communications chemistry · 2021Article
- A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system.Scientific reports · 2021Article
- Bioinspired interconnected hydrogel capsules for enhanced catalysis.RSC advances · 2018Article
- Multi-Layered Hydrogels for Biomedical Applications.Frontiers in chemistry · 2018Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diverse structures in nature, such as the spinal disc and the onion have many concentric layers, and are created starting from the core and proceeding outwards. Here, we demonstrate an inside-out technique for creating multilayered polymer capsules. First, an initiator-loaded gel core is placed in a solution of monomer 1. The initiator diffuses outward and induces polymerization, leading to a shell of polymer 1. Thereafter, the core-shell structure is loaded with fresh initiator and placed in monomer 2, which causes a concentric shell of polymer 2 to form around the first shell. This process can be repeated to form multiple layers, each of a distinct polymer, and of controlled layer thickness. We show that these multilayered capsules can exhibit remarkable mechanical resilience as well as stimuli-responsive properties. The release of solutes from these capsules can be tailored to follow specific profiles depending on the chemistry and order of adjacent layers.Multiple concentric layers are present in a variety of structures present in nature, including the onion. Here, the authors show an inside-out strategy to synthesize multilayered polymer capsules, with different layers having specific composition and thereby specific responses to stimuli such as pH and temperature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.