ArticleScientific reports2017
Robust circadian clock oscillation and osmotic rhythms in inner medulla reflecting cortico-medullary osmotic gradient rhythm in rodent kidney.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 39 citations in OpenAlex.
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- The Cardiac Circadian Clock Regulates Rhythms in Peripheral Tissues via Fibulin 5.Comprehensive physiology · 2026Article
- Diurnal function and expression of aquaporins in the mouse kidney.American journal of physiology. Renal physiology · 2025Article
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- Circadian clocks of the kidney: function, mechanism, and regulation.Physiological reviews · 2022Review
- Timing is everything: impact of development, ageing and circadian rhythm on macrophage functions in urinary tract infections.Mucosal immunology · 2022Review
- Effects of vasopressin receptor agonists on detrusor smooth muscle tone in young and aged bladders: Implications for nocturia treatment.Continence (Amsterdam, Netherlands) · 2022Article
- Olfactory receptors contribute to progression of kidney fibrosis.NPJ systems biology and applications · 2022Article
- Antidepressants and Circadian Rhythm: Exploring Their Bidirectional Interaction for the Treatment of Depression.Pharmaceutics · 2021Review
- Circadian Clock Regulation of Developmental Time in the Kidney.Cell reports · 2020Article
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- The intrinsic circadian clock in podocytes controls glomerular filtration rate.Scientific reports · 2019Article
- Circadian Clock Genes in Diabetic Kidney Disease (DKD).Current diabetes reports · 2019Review
- The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock.International journal of molecular sciences · 2019Article
- RECENT ADVANCES IN UNDERSTANDING THE CIRCADIAN CLOCK IN RENAL PHYSIOLOGY.Current opinion in physiology · 2018Article
- Circadian rhythms and the kidney.Nature reviews. Nephrology · 2018Review
- Circadian regulation of renal function.Free radical biology & medicine · 2018Review
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10 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Circadian clocks in mammals function in most organs and tissues throughout the body. Various renal functions such as the glomerular filtration and excretion of electrolytes exhibit circadian rhythms. Although it has been reported that the expression of the clock genes composing molecular oscillators show apparent daily rhythms in rodent kidneys, functional variations of regional clocks are not yet fully understood. In this study, using macroscopic bioluminescence imaging method of the PER2::Luciferase knock-in mouse kidney, we reveal that strong and robust circadian clock oscillation is observed in the medulla. In addition, the osmotic pressure in the inner medulla shows apparent daily fluctuation, but not in the cortex. Quantitative-PCR analysis of the genes contributing to the generation of high osmotic pressure or the water re-absorption in the inner medulla, such as vasopressin receptors (V1aR, V2R), urea transporter (UT-A2) and water channel (Aqp2) show diurnal variations as well as clock genes. Deficiency of an essential clock gene Bmal1 impairs day-night variations of osmotic pressure gradient in the inner medulla, suggesting that circadian clocks in the medulla part of the kidney may regulate the circadian rhythm of cortico-medullary osmotic pressure gradient, and may contribute physiological day-night rhythm of urination.
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