ArticleScientific reports2017
Defining a critical period for inhibitory circuits within the somatosensory cortex.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Rapid neuronal labeling and functional imaging in the developing mouse brain with AAV-PHP.eB.Cell reports methods · 2026Article
- Postnatal Development of Pyramidal Neurons Excitability and Synaptic Inputs in Mouse Gustatory Cortical Circuits.eNeuro · 2026Article
- Experience-dependent maturation of somatosensory parvalbumin interneurons during social development in prairie voles.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Postnatal development of pyramidal neurons excitability and synaptic inputs in mouse gustatory cortical circuits.bioRxiv : the preprint server for biology · 2025Article
- Presynaptic maturation of inhibitory connections onto vasoactive intestinal polypeptide-expressing GABAergic interneurons in the mouse barrel field.Pflugers Archiv : European journal of physiology · 2025Article
- Cognitive-Affective Functions of the Cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- An enriched environment ameliorates the reduction of parvalbumin-positive interneurons in the medial prefrontal cortex caused by maternal separation early in life.Frontiers in neuroscience · 2023Article
- Alcohol and lactation: Developmental deficits in a mouse model.Frontiers in neuroscience · 2023Article
- Article
- Shifting Developmental Trajectories During Critical Periods of Brain Formation.Frontiers in cellular neuroscience · 2020Review
- GABA Measurement in a Neonatal Fragile X Syndrome Mouse Model UsingFrontiers in molecular neuroscience · 2020Article
- Towards a better diagnosis and treatment of Rett syndrome: a model synaptic disorder.Brain : a journal of neurology · 2019Review
- Forever young: Neoteny, neurogenesis and a critique of critical periods in olfaction.Journal of bioenergetics and biomembranes · 2019Review
- A Randomized Controlled Trial of Sertraline in Young Children With Autism Spectrum Disorder.Frontiers in psychiatry · 2019Article
- A databank for intracellular electrophysiological mapping of the adult somatosensory cortex.GigaScience · 2018Article
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Authors and funding
3 authors.
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Abstract
Although experience-dependent changes in brain inhibitory circuits are thought to play a key role during the "critical period" of brain development, the nature and timing of these changes are poorly understood. We examined the role of sensory experience in sculpting an inhibitory circuit in the primary somatosensory cortex (S1) of mice by using optogenetics to map the connections between parvalbumin (PV) expressing interneurons and layer 2/3 pyramidal cells. Unilateral whisker deprivation decreased the strength and spatial range of inhibitory input provided to pyramidal neurons by PV interneurons in layers 2/3, 4 and 5. By varying the time when sensory input was removed, we determined that the critical period closes around postnatal day 14. This yields the first precise time course of critical period plasticity for an inhibitory circuit.
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