ArticleCirculation. Cardiovascular genetics2017
Effect of Disclosing Genetic Risk for Coronary Heart Disease on Information Seeking and Sharing: The MI-GENES Study (Myocardial Infarction Genes).
Article in Circulation. Cardiovascular genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01936675 (Myocardial Infarction Genes), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Myocardial Infarction Genes (MI-GENES) Study - Using Genomic Data to Refine Risk Assessment for Heart Attack
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Inherited risk of coronary artery disease: redefining care with imaging and genetics.Nature reviews. Cardiology · 2026Review
- Anatomy of the 23andMe fall and implications for consumer genomics.Nature biotechnology · 2025Article
- Article
- Attitudes toward returning pathogenicGenetics in medicine open · 2025Article
- Review
- Effect of disclosing a polygenic risk score for coronary heart disease on adverse cardiovascular events: 10-year follow-up of the MI-GENES randomized clinical trial.medRxiv : the preprint server for health sciences · 2024Article
- Article
- Simplified rules-based tool to facilitate the application of up-to-date management recommendations in cardio-oncology.Cardio-oncology (London, England) · 2023Article
- Education and electronic medical records and genomics network, challenges, and lessons learned from a large-scale clinical trial using polygenic risk scores.Genetics in medicine : official journal of the American College of Medical Genetics · 2023Review
- Polygenic Risk, Rare Variants, and Family History: Independent and Additive Effects on Coronary Heart Disease.JACC. Advances · 2023Article
- Patient similarity and other artificial intelligence machine learning algorithms in clinical decision aid for shared decision-making in the Prevention of Cardiovascular Toxicity (PACT): a feasibility trial design.Cardio-oncology (London, England) · 2023Article
- Clinical utility of polygenic risk scores for coronary artery disease.Nature reviews. Cardiology · 2022 · on this mapReview
- Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps.Nature medicine · 2021Review
- Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups.American journal of human genetics · 2020Article
- Associations of Combined Genetic and Lifestyle Risks With Incident Cardiovascular Disease and Diabetes in the UK Biobank Study.JAMA cardiology · 2018Article
- Cardiovascular Precision Medicine in the Genomics Era.JACC. Basic to translational science · 2018Review
- The Genetic Sphygmomanometer: an argument for routine genome-wide genotyping in the population and a new view on its use to inform clinical practice.Wellcome open research · 2018Article
- Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography.PloS one · 2018Observational
- Genetics in the 21st Century: Implications for patients, consumers and citizens.F1000Research · 2017Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWhether disclosing genetic risk for coronary heart disease (CHD) to individuals influences information seeking and information sharing is not known. We hypothesized that disclosing genetic risk for CHD to individuals influences information seeking and sharing. METHODS AND
resultsThe MI-GENES study (Myocardial Infarction Genes) randomized participants (n=203) aged 45 to 65 years who were at intermediate CHD risk based on conventional risk factors and not on statins to receive their conventional risk score alone or also a genetic risk score based on 28 variants. CHD risk was disclosed by a genetic counselor and then discussed with a physician. Surveys assessing information seeking were completed before and after risk disclosure. Information sharing was assessed post-disclosure. Six-month post-disclosure, genetic risk score participants were more likely than conventional risk score participants to visit a website to learn about CHD (odds ratio [OR], 4.88 [confidence interval (CI), 1.55-19.13];
conclusionsDisclosure of a genetic risk score for CHD increased information seeking and sharing. CLINICAL
trial registrationURL: https://clinicaltrials.gov/. Unique identifier: NCT01936675.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.