Evidence map›Paper›PMID 28778995›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Genetic background-dependent role of

Jangsuk Oh, Yujuan Wang, Shida Chen, Peng Li, Ning Du, Zu-Xi Yu, Donna Butcher, Tesfay Gebregiorgis, Erin Strachan, Ordan J Lehmann and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Jangsuk OhLaboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Yujuan WangLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892.
Shida ChenLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892.
Peng LiLaboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Ning DuLaboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Zu-Xi YuPathology Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Donna ButcherPathology/Histotechnology Laboratory, Leidos Biomedical Research, Inc., Frederick, MD 21702.
Tesfay GebregiorgisLaboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Erin StrachanDepartment of Medical Genetics, University of Alberta, Edmonton AB, Canada T6G 2H7.
Ordan J LehmannDepartment of Medical Genetics, University of Alberta, Edmonton AB, Canada T6G 2H7.
Brian P BrooksOphthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892.
Chi-Chao ChanLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892; wjl@helix.nih.gov chanc@nei.nih.gov.
Warren J LeonardLaboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; wjl@helix.nih.gov chanc@nei.nih.gov.
National Heart Lung and Blood Institute · USNational Institutes of Health · USUniversity of Alberta · CALeidos Biomedical Research Inc. (United States)National Eye Institute · US

Funding

IL-2 Family Cytokines and their Receptors-- Molecular Regulation via STATsZIAHL005402 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEONARD, WARREN J · 2009 to 2025
$26.8M
Pathology CoreZICHL005904 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI YU, ZU XI · 2010 to 2023
$11.6M
6 · The paper itself

Abstract

EGR1 is an early growth response zinc finger transcription factor with broad actions, including in differentiation, mitogenesis, tumor suppression, and neuronal plasticity. Here we demonstrate that

Indexed as

AnimalsEarly Growth Response Protein 1EyeEyelidsGene Expression Regulation, DevelopmentalMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutEarly Growth Response Protein 1Egr1eyelid developmentgenetic background-specific effectsocular abnormalitiestyrosinase

Identifiers

PMID28778995
PMCPMC5576810
OpenAlexW2744236171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.