Evidence map›Paper›PMID 28778919›Full record

ArticleThorax2018

The top 10 research priorities in cystic fibrosis developed by a partnership between people with CF and healthcare providers.

Nicola J Rowbotham, Sherie Smith, Paul A Leighton, Oli C Rayner, Katie Gathercole, Zoe C Elliott, Edward F Nash, Tracey Daniels, Alistair J A Duff, Sarah Collins and 5 more

Abstract readLetterMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Thorax, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Physical activity and exercise training in cystic fibrosis.The Cochrane database of systematic reviews · 2022
    Pooled it
  4. Short-acting inhaled bronchodilators for cystic fibrosis.The Cochrane database of systematic reviews · 2022
    Pooled it
  5. Exercise versus airway clearance techniques for people with cystic fibrosis.The Cochrane database of systematic reviews · 2022
    Pooled it
  6. Pooled it
  7. Priorities of patients, caregivers and health-care professionals for health research - A systematic review.Health expectations : an international journal of public participation in health care and health policy · 2020
    Pooled it
  8. Pooled it
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  20. Elexacaftor/tezacaftor/ivacaftor is associated with long-term reduction in use of chronic respiratory therapies in cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2026
    Observational

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nicola J RowbothamEvidence Based Child Health Group, University of Nottingham, Nottingham, UK.
Sherie SmithEvidence Based Child Health Group, University of Nottingham, Nottingham, UK.
Paul A LeightonSchool of Medicine, NIHR Research Design Service for the East Midlands, University of Nottingham, Nottingham, UK.
Oli C RaynerPerson with Cystic Fibrosis, Plymouth, UK.
Katie GathercolePerson with Cystic Fibrosis, Plymouth, UK.
Zoe C ElliottParent of Children with CF, Nottingham, UK.
Edward F NashWest Midlands Adult CF Centre, Heart of England NHS Foundation Trust, Birmingham, UK.
Tracey DanielsDepartment of Physiotherapy, York Hull Adult CF Unit, York Teaching Hospital NHS Foundation Trust, York, UK.
Alistair J A DuffDepartment of Clinical Psychology, Leeds Teaching Hospital NHS Trust, Leeds, UK.
Sarah CollinsDepartment of CF, Royal Brompton and Harefield NHS Trust, London, UK.
Suja ChandranRegional Paediatric CF Centre, Kings College Hospital, London, UK.
Ursula PeapleNational Team Specialised Commissioning, NHS England, London, UK.
Matthew N HurleyEvidence Based Child Health Group, University of Nottingham, Nottingham, UK.ORCID 0000-0002-2439-8522
Keith BrownleeCystic Fibrosis Trust, London, UK.
Alan R SmythEvidence Based Child Health Group, University of Nottingham, Nottingham, UK.ORCID 0000-0001-5494-5438

Funding

Department of Health
6 · The paper itself

Abstract

There remain many treatment uncertainties in cystic fibrosis (CF). With limited resources, research should focus on questions which are most important to the CF community. We conducted a James Lind Alliance Priority Setting Partnership in CF. Research questions were elicited and then prioritised in successive surveys. A workshop agreed the final top 10. Online methods avoided cross infection and widened participation. The elicitation survey had 482 respondents (1080 questions) and prioritisation survey 677 respondents. Participants were drawn equally from the patient and clinical communities globally. We have achieved a consensus on 10 research priorities which will be attractive to funders.

Indexed as

AdolescentAdultAgedAged, 80 and overAustraliaCanadaChildCystic FibrosisEuropeFemaleHealth PersonnelHealth PrioritiesHumansMaleMiddle AgedNew Zealandcystic fibrosispatient engagementresearch priorities

Identifiers

PMID28778919
PMCPMC5870449

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.