Evidence map›Paper›PMID 28778790›Full record

ArticleEnvironmental pollution (Barking, Essex : 1987)2017

Partitioning of hexachlorobenzene between human milk and blood lipid.

Ľubica Palkovičová Murínová, Soňa Wimmerová, Kinga Lancz, Henrieta Patayová, Vladimíra Koštiaková, Denisa Richterová, Eva Govarts, Todd A Jusko, Tomáš Trnovec

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental pollution (Barking, Essex : 1987), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Analysis of the Influence ofMolecules (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Ľubica Palkovičová MurínováDepartment of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia.
Soňa WimmerováDepartment of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia.
Kinga LanczDepartment of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia.
Henrieta PatayováDepartment of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia.
Vladimíra KoštiakováDepartment of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia.
Denisa RichterováDepartment of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia.
Eva GovartsUnit Environmental Risk and Health, VITO NV, Boeretang 200, 2400 Mol, Belgium.
Todd A JuskoDepartments of Public Health Sciences and Environmental Medicine, University of Rochester, School of Medicine & Dentistry, 265 Crittenden Blvd, CU 420644, Rochester, NY 14642, United States.
Tomáš TrnovecDepartment of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia. Electronic address: tomas.trnovec@szu.sk.
Slovak Medical University · SKFlemish Institute for Technological Research · BEUniversity of Rochester · US

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Martha Susiarjo · 1985 to 2026
$42.8M
Early Childhood Development and PCB Exposures in Slovak*R01CA096525 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI HERTZ-PICCIOTTO, IRVA · 2001 to 2005
$2.3M
Women's Health and the Environment over the Entire Lifespan (WHEEL)K12ES019852 · NIEHS · UNIVERSITY OF ROCHESTER · PI CORY-SLECHTA, DEBORAH A · 2010 to 2014
$1.8M
PCBs and Otodevelopment in Eastern SlovakiaR03TW007152 · FIC · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HERTZ-PICCIOTTO, IRVA · 2006 to 2008
$100k
FIC NIH HHS R03 TW007152NCI NIH HHS R01 CA096525NIEHS NIH HHS K12 ES019852NIEHS NIH HHS P30 ES001247
6 · The paper itself

Abstract

In epidemiological studies on the toxic effects of prenatal exposure to hexachlorobenzene (HCB), researchers report HCB concentrations, either as wet-weight or per lipid weight basis, in matrices like breast milk, and maternal and cord blood. Conversion of exposures across matrices is needed for comparisons of concentrations and dose effect across cohorts. Using data from a birth cohort study in eastern Slovakia, we derived the maternal blood to cord blood HCB concentration ratio utilizing measured concentrations in 1027 paired maternal and cord blood samples, on a per-lipid basis. In addition to data from the Slovak study, the maternal milk to maternal serum ratio was summarized from 23 published studies on partitioning of HCB between human milk lipid and blood lipid. We identified two distinct groups of milk:blood ratios, those ≤0.45 and those ≥0.85. We assumed that using partition ratios ≤0.45 will underestimate HCB exposure estimates. Taking into account this precautionary measure, we suggest a conversion ratio of 1.21, which is the median of the 16 ratios identified in our literature review. We consider our estimate as conservative and providing appropriate safety in risk analysis.

Indexed as

AdultCohort StudiesEnvironmental PollutantsFemaleFetal BloodHexachlorobenzeneHumansLipidsMaternal ExposureMilk, HumanSlovakiaEnvironmental PollutantsHexachlorobenzeneLipidsBreast milkConcentration conversionCord bloodHexachlorobenzeneLipidsPartitioning

Identifiers

PMID28778790
PMCPMC6044446
OpenAlexW2740771768

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.