Evidence map›Paper›PMID 28778681›Full record

ArticleTrends in genetics : TIG2017

On the Origin of lncRNAs: Missing Link Found.

Joaquín M Espinosa

Abstract readComment
In one paragraph

Article in Trends in genetics : TIG, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Super enhancer lncRNAs: a novel hallmark in cancer.Cell communication and signaling : CCS · 2024
    Review
  5. Article
  6. Non-Coding RNAs in Response to Drought Stress.International journal of molecular sciences · 2021
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Enhancer RNAs are an important regulatory layer of the epigenome.Nature structural & molecular biology · 2020
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Joaquín M EspinosaLinda Crnic Institute for Down Syndrome and Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Boulder, CO 80203, USA. Electronic address: joaquin.espinosa@ucdenver.edu.

Funding

Stress- and Promoter-Specific Mechanisms of Transcritpional Activation by p53R01CA117907 · NCI · UNIVERSITY OF COLORADO DENVER · PI ESPINOSA, JOAQUIN M. · 2006 to 2022
$4.4M
Mechanisms of gene expression control during the cellular response to hypoxiaR01GM120109 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI ESPINOSA, JOAQUIN M. · 2016 to 2019
$1.2M
NCI NIH HHS R01 CA117907NIGMS NIH HHS R01 GM120109
6 · The paper itself

Abstract

Non-coding (nc)RNAs known as enhancer-derived RNAs (eRNAs) and as long ncRNAs (lncRNAs) have received much attention, but their true functional specialization and evolutionary origins remain obscure. The recent characterization of Bloodlinc, an eRNA derived from a super-enhancer that also functions as a lncRNA, suggests that lncRNAs can evolve from eRNAs.

Indexed as

Enhancer Elements, GeneticEvolution, MolecularHumansRNA, Long NoncodingRNA, Long Noncodingchromatin loopCTCFeRNAlncRNAnoncoding RNAsuperenhancertopological activation domain

Identifiers

PMID28778681
PMCPMC5610073

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.