Evidence map›Paper›PMID 28778505›Full record

ArticleJournal of endodontics2017

Lipoprotein Receptor-related Protein 6 Signaling is Necessary for Vasculogenic Differentiation of Human Dental Pulp Stem Cells.

Gleyce O Silva, Zhaocheng Zhang, Carolina Cucco, Min Oh, Carlos H R Camargo, Jacques E Nör

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of endodontics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Angiogenic regulation of dental pulp stem cells.Frontiers in dental medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Gleyce O SilvaDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan; Department of Restorative Dentistry, Institute of Science and Technology, São Paulo State University, São José dos Campos, São Paulo, Brazil.
Zhaocheng ZhangDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan.
Carolina CuccoDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan.
Min OhDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan.
Carlos H R CamargoDepartment of Restorative Dentistry, Institute of Science and Technology, São Paulo State University, São José dos Campos, São Paulo, Brazil.
Jacques E NörDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan; Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan; Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, Michigan; Department of Otolaryngology, University of Michigan School of Medicine, Ann Arbor, Michigan. Electronic address: jenor@umich.edu.
University of Michigan–Ann Arbor · USMichigan Center for Translational Pathology · USUniversidade Estadual Paulista (Unesp) · BR

Funding

Mechanisms of dental pulp stem cell differentiation into functional endotheliumR01DE021410 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NOR, JACQUES EDUARDO · 2011 to 2021
$3.2M
Regulation of dental pulp stem cell fateR37DE021410 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jacques Eduardo Nor · 2024 to 2026
$1.2M
Perivascular Niche and Self-Renewal of Dental Pulp Stem CellsF30DE025471 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OH, MIN · 2015 to 2018
$171k
NIDCR NIH HHS F30 DE025471NIDCR NIH HHS R01 DE021410NIDCR NIH HHS R37 DE021410
6 · The paper itself

Abstract

The aim of this study was to evaluate the effects of Wnt signaling through lipoprotein receptor-related protein 6 (LRP6) and Frizzled6 on the endothelial differentiation of dental pulp stem cells (DPSCs). DPSCs were stably transduced with enhanced green fluorescent protein (EGFP)-tagged lentiviral vectors (short hairpin RNA-LRP6, short hairpin RNA-Frizzled6, or empty vector controls). We evaluated the effects of LRP6 and Frizzled6 on expression of endothelial markers and on capillary tube formation mediated by DPSCs induced with recombinant human Wnt1 (rhWnt1) and/or recombinant human vascular endothelial growth factor

Indexed as

Signal TransductionAnimalsCell DifferentiationCells, CulturedDental PulpHumansLow Density Lipoprotein Receptor-Related Protein-6MiceStem CellsVascular Endothelial Growth Factor AWnt Signaling PathwayLow Density Lipoprotein Receptor-Related Protein-6Vascular Endothelial Growth Factor AVEGFA protein, humanAngiogenesiscell fateregenerative endodonticstissue engineeringWnt

Identifiers

PMID28778505
PMCPMC5657009
OpenAlexW2739968845

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.