ArticleJournal of biomechanics2017
Crosslinked elastic fibers are necessary for low energy loss in the ascending aorta.
Article in Journal of biomechanics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Severe αRespiratory research · 2022Pooled it
- Analysis of Energy Dissipation Ratio in Commercial Bovine Pericardial Patches Treated with Glutaraldehyde Solution.Journal of functional biomaterials · 2026Article
- Epigallocatechin gallate (EGCG) partially prevents elastase-induced mechanical and microstructural changes in the mouse ascending aorta in vitro.Journal of the mechanical behavior of biomedical materials · 2026Article
- Variations in stiffness and structure of the human aorta along its length.Scientific reports · 2025Article
- Effects of age, elastin density, and glycosaminoglycan accumulation on the delamination strength of human thoracic and abdominal aortas.Acta biomaterialia · 2024Article
- Age- and sex-specific biomechanics and extracellular matrix remodeling of the ascending aorta in a mouse model of severe Marfan syndrome.American journal of physiology. Heart and circulatory physiology · 2024Article
- A review of current status of cell-based therapies for aortic aneurysms.Inflammation and regeneration · 2023Review
- Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics.Acta biomaterialia · 2023Article
- Effect of aging on the biaxial mechanical behavior of human descending thoracic aorta: Experiments and constitutive modeling considering collagen crosslinking.Journal of the mechanical behavior of biomedical materials · 2023Article
- Elastin, arterial mechanics, and stenosis.American journal of physiology. Cell physiology · 2022Review
- Enigma of aortic aneurysms continues to be enigmatic!Indian journal of thoracic and cardiovascular surgery · 2022Article
- Passive biaxial mechanical behavior of newborn mouse aorta with and without elastin.Journal of the mechanical behavior of biomedical materials · 2022Article
- Biomechanical Properties of Mouse Carotid Arteries With Diet-Induced Metabolic Syndrome and Aging.Frontiers in bioengineering and biotechnology · 2022Article
- Pentagalloyl glucose (PGG) partially prevents arterial mechanical changes due to elastin degradation.Experimental mechanics · 2021Article
- Bio-chemo-mechanics of the thoracic aorta.Vascular biology (Bristol, England) · 2021Review
- Elastin haploinsufficiency in mice has divergent effects on arterial remodeling with aging depending on sex.American journal of physiology. Heart and circulatory physiology · 2020Article
- Integral role for lysyl oxidase-like-1 in conventional outflow tissue function and behavior.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Captopril treatment during development alleviates mechanically induced aortic remodeling in newborn elastin knockout mice.Biomechanics and modeling in mechanobiology · 2020Article
- Recent Advances in Biomechanical Characterization of Thoracic Aortic Aneurysms.Frontiers in cardiovascular medicine · 2020Review
- Coordinated development of the mouse extrahepatic bile duct: Implications for neonatal susceptibility to biliary injury.Journal of hepatology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
In the large arteries, it is believed that elastin provides the resistance to stretch at low pressure, while collagen provides the resistance to stretch at high pressure. It is also thought that elastin is responsible for the low energy loss observed with cyclic loading. These tenets are supported through experiments that alter component amounts through protease digestion, vessel remodeling, normal growth, or in different artery types. Genetic engineering provides the opportunity to revisit these tenets through the loss of expression of specific wall components. We used newborn mice lacking elastin (Eln
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.