ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2017
Early assessment of dosimetric and biological differences of total marrow irradiation versus total body irradiation in rodents.
Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Preliminary high-dose irradiation of the recipient and associated damage of bone marrow stromal compartment enables bone marrow stroma transplantation.Scientific reports · 2025Article
- An efficient rectangular optimization method for sparse orthogonal collimator based small animal irradiation.Physics in medicine and biology · 2022Article
- Impact of total marrow/lymphoid irradiation dose to the intestine on graft-versus-host disease in allogeneic hematopoietic stem cell transplantation for hematologic malignancies.Frontiers in oncology · 2022Article
- Feasibility of a Novel Sparse Orthogonal Collimator-Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality.Frontiers in oncology · 2022Article
- Clinical study of total bone marrow combined with total lymphatic irradiation pretreatment based on tomotherapy in hematopoietic stem cell transplantation of acute leukemia.Frontiers in oncology · 2022Article
- Total marrow irradiation reduces organ damage and enhances tissue repair with the potential to increase the targeted dose of bone marrow in both young and old mice.Frontiers in oncology · 2022Article
- Long-term follow up of patients with hematological malignancies treated with total body irradiation using intensity modulated radiation therapy.Frontiers in oncology · 2022Article
- First Multimodal, Three-Dimensional, Image-Guided Total Marrow Irradiation Model for Preclinical Bone Marrow Transplantation Studies.International journal of radiation oncology, biology, physics · 2021Article
- Biophysical Characterization of the Leukemic Bone Marrow Vasculature Reveals Benefits of Neoadjuvant Low-Dose Radiation Therapy.International journal of radiation oncology, biology, physics · 2021Article
- [Containing total marrow irradiation conditioning regimen for patients with leukemia undergoing hematopoietic stem cell transplantation].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2020Article
- A sparse orthogonal collimator for small animal intensity-modulated radiation therapy. Part II: hardware development and commissioning.Medical physics · 2019Article
- Bone marrow chimeras-a vital tool in basic and translational research.Journal of molecular medicine (Berlin, Germany) · 2019Review
- Energy-dependent OAR sparing and dose conformity for total marrow irradiation of obese patients.Journal of applied clinical medical physics · 2018Article
- Total marrow irradiation-based conditioning for allogeneic hematopoietic stem cell transplantation in patients with hematologic malignancies: A multicenter real-world study.Cell transplantationArticle
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17 authors.
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Abstract
purposeTo develop a murine total marrow irradiation (TMI) model in comparison with the total body irradiation (TBI) model. MATERIALS AND
methodsMyeloablative TMI and TBI were administered in mice using a custom jig, and the dosimetric differences between TBI and TMI were evaluated. The early effects of TBI/TMI on bone marrow (BM) and organs were evaluated using histology, FDG-PET, and cytokine production. TMI and TBI with and without cyclophosphamide (Cy) were evaluated for donor cell engraftment and tissue damage early after allogeneic hematopoietic cell transplantation (HCT). Stromal derived factor-1 (SDF-1) expression was evaluated.
resultsTMI resulted in similar dose exposure to bone and 50% reduction in dose to bystander organs. BM histology was similar between the groups. In the non-HCT model, TMI mice had significantly less acute intestinal and lung injury compared to TBI. In the HCT model, recipients of TMI had significantly less acute intestinal injury and spleen GVHD, but increased early donor cell engraftment and BM:organ SDF-1 ratio compared to TBI recipients.
conclusionsThe expected BM damage was similar in both models, but the damage to other normal tissues was reduced by TMI. However, BM engraftment was improved in the TMI group compared to TBI, which may be due to enhanced production of SDF-1 in BM relative to other organs after TMI.
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