ArticleBMC infectious diseases2017
The invasome of Salmonella Dublin as revealed by whole genome sequencing.
Article in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 66 citations in OpenAlex.
- Review
- Cross-species genomic analysis ofOne health (Amsterdam, Netherlands) · 2026Article
- Disseminated multidrug-resistant Salmonella enterica serovar Dublin infection associated with plasmid-borne CMY-2 gene in a patient with travel to a farm in Mexico.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Article
- Article
- Genomic epidemiology and phenotypic characterisation of Salmonella enterica serovar Panama in Victoria, Australia.PLoS neglected tropical diseases · 2024Article
- Prevalence and Antimicrobial Resistance Diversity ofAntibiotics (Basel, Switzerland) · 2024Article
- Genomic analysis of Anderson typing phages of Salmonella Typhimrium: towards understanding the basis of bacteria-phage interaction.Scientific reports · 2023Article
- From the Gut to the Heart: A Rare Case of Salmonella dublin Pericarditis.The American journal of case reports · 2023Article
- Geography shapes the genomics and antimicrobial resistance of Salmonella enterica Serovar Enteritidis isolated from humans.Scientific reports · 2023Article
- Review:Frontiers in veterinary science · 2023Review
- Clonal relation betweenFrontiers in veterinary science · 2023Article
- Draft genome sequences data of fourData in brief · 2022Article
- Whole genome sequencing analyses revealed that Salmonella enterica serovar Dublin strains from Brazil belonged to two predominant clades.Scientific reports · 2022Article
- Whole-Genome Investigation ofMicroorganisms · 2022Article
- Epidemiology ofFrontiers in microbiology · 2022Article
- Safety of theFrontiers in veterinary science · 2022Article
- The European Union One Health 2020 Zoonoses Report.EFSA journal. European Food Safety Authority · 2021Article
- Epidemiological Analysis of Salmonella enterica subsp.Microbiology spectrum · 2021Article
- Characterisation of Phage Susceptibility Variation inMicroorganisms · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSalmonella enterica serovar Dublin is a zoonotic infection that can be transmitted from cattle to humans through consumption of contaminated milk and milk products. Outbreaks of human infections by S. Dublin have been reported in several countries including high-income countries. A high proportion of S. Dublin cases in humans are associated with invasive disease and systemic illness. The genetic basis of virulence in S. Dublin is not well characterized.
methodsWhole genome sequencing was applied to a set of clinical invasive and non-invasive S. Dublin isolates from different countries in order to characterize the putative genetic determinants involved in the virulence and invasiveness of S. Dublin in humans.
resultsWe identified several virulence factors that form the bacterial invasome and may contribute to increasing bacterial virulence and pathogenicity including mainly Gifsy-2 prophage, two different type 6 secretion systems (T6SSs) harbored by Salmonella pathogenicity islands; SPI-6 and SPI-19 respectively and virulence genes; ggt and PagN. Although Vi antigen and the virulence plasmid have been reported previously to contribute to the virulence of S. Dublin we did not detect them in all invasive isolates indicating that they are not the main virulence determinants in S. Dublin.
conclusionSeveral virulence factors within the genome of S. Dublin might contribute to the ability of S. Dublin to invade humans' blood but there were no genomic markers that differentiate invasive from non-invasive isolates suggesting that host immune response play a crucial role in the clinical outcome of S. Dublin infection.
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