Evidence map›Paper›PMID 28777940›Full record

ArticleCell stem cell2017

A Little Bit of Guidance: Mini Brains on Their Route to Adolescence.

Philipp Koch, Julia Ladewig

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Modeling Neurological Diseases With Human Brain Organoids.Frontiers in synaptic neuroscience · 2018
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Philipp KochInstitute of Reconstructive Neurobiology, University of Bonn, Bonn, 53127, Germany.
Julia LadewigInstitute of Reconstructive Neurobiology, University of Bonn, Bonn, 53127, Germany. Electronic address: jladewig@uni-bonn.de.

Funding

Medical Research Council MC_UP_1201/9
6 · The paper itself

Abstract

Cerebral organoids represent a new model in which to study human brain development outside the human body. Recently in Nature Biotechnology, Lancaster et al. (2017) tackled the lack of reproducibility, tissue homogeneity, and complexity of this system by bioengineering organoids to establish the next generation of human mini brains.

Indexed as

BrainOrganoidsAdolescentCerebral CortexHumansOrganogenesisReproducibility of Results

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.