Evidence map›Paper›PMID 28777932›Full record

ArticleAmerican journal of human genetics2017

Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage.

Joshua A Betts, Mahdi Moradi Marjaneh, Fares Al-Ejeh, Yi Chieh Lim, Wei Shi, Haran Sivakumaran, Romain Tropée, Ann-Marie Patch, Michael B Clark, Nenad Bartonicek and 21 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 97 citations in OpenAlex.

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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 4 institutions in 2 countries.

Joshua A BettsCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia.
Mahdi Moradi MarjanehCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Fares Al-EjehCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Yi Chieh LimCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Wei ShiCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Haran SivakumaranCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Romain TropéeQueensland University of Technology at the Translational Research Institute, Brisbane, QLD 4102, Australia.
Ann-Marie PatchCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Michael B ClarkDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX1 2JD, UK; Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
Nenad BartonicekGarvan Institute of Medical Research, Sydney, NSW 2010, Australia; St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Adrian P WiegmansCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Kristine M HillmanCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Susanne KaufmannCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Amanda L BainCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Brian S GlossGarvan Institute of Medical Research, Sydney, NSW 2010, Australia; St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Joanna CrawfordInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.
Stephen KazakoffCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Shivangi WaniCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Shu W WenCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Bryan DayCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Andreas MöllerCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Nicole CloonanCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
John PearsonCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Melissa A BrownSchool of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia.
Timothy R MercerGarvan Institute of Medical Research, Sydney, NSW 2010, Australia; St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Nicola WaddellCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Kum Kum KhannaCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Eloise DrayQueensland University of Technology at the Translational Research Institute, Brisbane, QLD 4102, Australia; Queensland University of Technology, Institute of Health and Biomedical Innovation, Brisbane, QLD 4059, Australia.
Marcel E DingerGarvan Institute of Medical Research, Sydney, NSW 2010, Australia; St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Stacey L EdwardsCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia. Electronic address: stacey.edwards@qimrberghofer.edu.au.
Juliet D FrenchCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia. Electronic address: juliet.french@qimrberghofer.edu.au.
QIMR Berghofer Medical Research Institute · AUGarvan Institute of Medical Research · AUThe University of Queensland · AUTranslational Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a distal enhancer that regulates CCND1. Here, we report that, in addition to regulating CCND1, this enhancer regulates two estrogen-regulated long noncoding RNAs, CUPID1 and CUPID2. We provide evidence that the risk-associated SNPs are associated with reduced chromatin looping between the enhancer and the CUPID1 and CUPID2 bidirectional promoter. We further show that CUPID1 and CUPID2 are predominantly expressed in hormone-receptor-positive breast tumors and play a role in modulating pathway choice for the repair of double-strand breaks. These data reveal a mechanism for the involvement of this region in breast cancer.

Indexed as

Breast NeoplasmsCell Line, TumorChromatinChromosomes, Human, Pair 11Cyclin D1DNA Breaks, Double-StrandedDNA DamageDNA RepairEnhancer Elements, GeneticEstrogensFemaleGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseHumansMCF-7 CellsPolymorphism, Single NucleotideCCND1 protein, humanChromatinCyclin D1EstrogensRNA, Guide, CRISPR-Cas SystemsRNA, Long NoncodingRNA, Small Interfering11q13breast cancerDNA repairenhancerGWASlong noncoding RNAs

Identifiers

PMID28777932
PMCPMC5544418
OpenAlexW2742662638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.