ArticlePloS one2017
Gluc-HET, a complementary chick embryo model for the characterization of antidiabetic compounds.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Study of the Hypoglycemic Activity of Rhamnolipids Using theCurrent issues in molecular biology · 2026Article
- Exogenous melatonin alleviates abnormal glucose metabolism in the breast muscle under long-term light exposure through the parasympathetic pathway.Journal of advanced research · 2026Article
- Identification of Plant Phenolics fromJournal of agricultural and food chemistry · 2025Article
- Short-term exposure of 2.4 GHz electromagnetic radiation on cellular ROS generation and apoptosis in SH-SY5Y cell line and impact on developing chick embryo brain tissue.Molecular biology reports · 2025Article
- Primordial germ cells as a potential model for understanding (Nutri) epigenetic - metabolic interactions: a mini review.Frontiers in cell and developmental biology · 2025Review
- Insulin-Mimetic Activity of Herbal Extracts Identified with Large-Scale Total Internal Reflection Fluorescence Microscopy.Nutrients · 2024Article
- Investigating the teratogenic potential of diclofenac sodium on chick embryos: A warning for pregnant women.Toxicology reports · 2024Article
- A comprehensiveFrontiers in pharmacology · 2024Review
- Formulation and Characterization of Epalrestat-Loaded Polysorbate 60 Cationic Niosomes for Ocular Delivery.Pharmaceutics · 2023Article
- An Untargeted Lipidomics Study of Acute Ischemic Stroke with Hyperglycemia Based on Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry.Computational and mathematical methods in medicine · 2022Article
- Empagliflozin induces apoptotic-signaling pathway in embryonic vasculature:Frontiers in pharmacology · 2022Article
- A novel model of early type 1 diabetes mellitus: The chick embryo air sack model.Saudi journal of biological sciences · 2021Article
- Identification of Insulin-Mimetic Plant Extracts: From an In Vitro High-Content Screen to Blood Glucose Reduction in Live Animals.Molecules (Basel, Switzerland) · 2021Article
- In vivo evidence of angiogenesis inhibition by β2-glycoprotein I subfractions in the chorioallantoic membrane of chicken embryos.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Article
- Avens Root (Frontiers in pharmacology · 2021Article
- Hypolipidemic effects of herbal extracts by reduction of adipocyte differentiation, intracellular neutral lipid content, lipolysis, fatty acid exchange and lipid droplet motility.Scientific reports · 2019Article
- Insulin Mimetic Properties of Extracts Prepared fromMolecules (Basel, Switzerland) · 2018Article
- In Vitro and In Vivo Inhibition of Intestinal Glucose Transport by Guava (Psidium Guajava) Extracts.Molecular nutrition & food research · 2018Article
- An In Ovo Model for Testing Insulin-mimetic Compounds.Journal of visualized experiments : JoVE · 2018Article
- Embryonic toxico-pathological effects of meglumine antimoniate using a chick embryo model.PloS one · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance and β cell failure are the main causes of elevated blood glucose levels in Type 2 diabetes mellitus (T2DM), a complex and multifactorial metabolic disease. Several medications to treat or reduce the symptoms of T2DM are used, including the injection of insulin and the application of insulin sensitizing or glucose production reducing drugs. Furthermore, the use of phytochemicals has attracted increasing attention for the therapy and prevention of T2DM. In order to identify and characterize antidiabetic compounds, efficient test systems are required. Here we present a modified chick embryo model (hens egg test, HET), which has originally been developed to determine the potential irritancy of chemicals, as a versatile tool for the characterization of phytochemicals with antidiabetic properties. We termed this modified assay variation Gluc-HET. More precisely, we determined the influence of variations in the incubation time of the fertilized eggs and studied the effects of different buffer parameters, such as the temperature, composition and volume, used for drug application. In addition, we tested several putative antidiabetic plant extracts, which have been identified in an in-vitro primary screening procedure, for their effectiveness in reducing blood glucose levels in-ovo. Taken together, our Gluc-HET model has proven to be a reliable and manageable system for the characterization of antidiabetic compounds.
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