ArticleJournal of the American Chemical Society2017
Site-Selective Sensing of Histone Methylation Enzyme Activity via an Arrayed Supramolecular Tandem Assay.
Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome.Molecular cell · 2019Pooled it
- Nanomolar Affinity Host-Dye Reporter Pairs from Fluorescently Labeled Oligoarginine Peptides and p-Sulfonatocalix[4]arene.Chembiochem : a European journal of chemical biology · 2026Article
- A Column Chromatography-Free Protocol for the Synthesis of Water-Soluble Cavitands.The Journal of organic chemistry · 2025Article
- Enrichment of histone tail methylated lysine residuesChemical science · 2024Article
- Molecular recognition of methylated amino acids and peptides by Pillar[6]MaxQ.Organic & biomolecular chemistry · 2022Article
- Enzyme assays with supramolecular chemosensors - the label-free approach.RSC advances · 2022Review
- Selective discrimination and classification of G-quadruplex structures with a host-guest sensing array.Nature chemistry · 2021Article
- Fluorogenic probes for detecting deacylase and demethylase activity towards post-translationally-modified lysine residues.Chemical science · 2021Article
- Selective Recognition of Amino Acids and Peptides by Small Supramolecular Receptors.Molecules (Basel, Switzerland) · 2020Review
- Cationic Pillar[6]arene Induces Cell Apoptosis by Inhibiting Protein Tyrosine Phosphorylation Via Host-Guest Recognition.International journal of molecular sciences · 2020Article
- Tuning the anion binding properties of lanthanide receptors to discriminate nucleoside phosphates in a sensing array.Chemical science · 2020Article
- Introducing Seven Transition Metal Ions into Terpyridine-Based Supramolecules: Self-Assembly and Dynamic Ligand Exchange Study.Journal of the American Chemical Society · 2020Article
- Sensing of citrulline modifications in histone peptides by deep cavitand hosts.Chemical communications (Cambridge, England) · 2019Article
- A simple, robust, universal assay for real-time enzyme monitoring by signalling changes in nucleoside phosphate anion concentration using a europium(iii)-based anion receptor.Chemical science · 2019Article
- Recent Advances in Design of Fluorescence-Based Assays for High-Throughput Screening.Analytical chemistry · 2019Review
- Probing the Structural Determinants of Amino Acid Recognition: X-Ray Studies of Crystalline Ditopic Host-Guest Complexes of the Positively Charged Amino Acids, Arg, Lys, and His with a Cavitand Molecule.Molecules (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Arrayed deep cavitands can be coupled to a fluorescence-based supramolecular tandem assay that allows site-selective in situ monitoring of post-translational modifications catalyzed by the lysine methyltransferase PRDM9 or the lysine demethylase JMJD2E. An arrayed sensor system containing only three cavitand components can detect the specific substrates of enzyme modification, in the presence of other histone peptides in the enzyme assay, enabling investigation of cross-reactivity over multiple methylation sites and interference from nonsubstrate peptides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.