Evidence map›Paper›PMID 28777347›Full record

ArticleMolecules (Basel, Switzerland)2017

γ-Tocotrienol Inhibits Proliferation and Induces Apoptosis Via the Mitochondrial Pathway in Human Cervical Cancer HeLa Cells.

Weili Xu, Yaqing Mi, Pan He, Shenghua He, Lingling Niu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Revisiting the therapeutic potential of tocotrienol.BioFactors (Oxford, England) · 2022
    Review
  8. Review
  9. Article
  10. Vitamin E beyond Its Antioxidant Label.Antioxidants (Basel, Switzerland) · 2021
    Review
  11. Article
  12. Review
  13. Review
  14. Tocotrienols Modulate a Life or Death Decision in Cancers.International journal of molecular sciences · 2019
    Review
  15. Review
  16. Review
  17. Special Issue: Natural Products: Anticancer and Beyond.Molecules (Basel, Switzerland) · 2018
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Weili XuDepartment of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, 150001 Harbin, China. weilixu@hit.edu.cn.
Yaqing MiDepartment of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, 150001 Harbin, China. yaqingmi@163.com.
Pan HeDepartment of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, 150001 Harbin, China. 16s125207@stu.hit.edu.cn.
Shenghua HeDepartment of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, 150001 Harbin, China. heshenghua@hit.edu.cn.
Lingling NiuDepartment of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, 150001 Harbin, China. niulingling2016@126.com.
Harbin Institute of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

γ-Tocotrienol, a kind of isoprenoid phytochemical, has antitumor activity. However, there is limited evidence that it has an effect on cervical cancer. In this study, the capacity to inhibit proliferation and induce apoptosis in human cervical cancer HeLa cells and the mechanism underlying these effects were examined. The results indicated that a γ-tocotrienol concentration over 30 μM inhibited the growth of HeLa cells with a 50% inhibitory concentration (IC

Indexed as

ApoptosisCell ProliferationFemalegamma-TocopherolHeLa CellsHumansMitochondriaNeoplasm ProteinsUterine Cervical Neoplasmsgamma-TocopherolNeoplasm Proteinsapoptosiscell proliferationcervical cancerγ-tocotrienol

Identifiers

PMID28777347
PMCPMC6152108
OpenAlexW2743398026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.