ArticleInternational journal of molecular sciences2017
In Situ Forming Gelatin Hydrogels-Directed Angiogenic Differentiation and Activity of Patient-Derived Human Mesenchymal Stem Cells.
Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Current status and new horizons in stem cell therapy in cardiovascular regenerative medicine (CaVaReM): an update.European journal of medical research · 2025Review
- A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair.Frontiers in bioengineering and biotechnology · 2022Review
- The progress in titanium alloys used as biomedical implants: From the view of reactive oxygen species.Frontiers in bioengineering and biotechnology · 2022Review
- Platelet-Derived Growth Factor Stimulated Migration of Bone Marrow Mesenchymal Stem Cells into an Injectable Gelatin-Hydroxyphenyl Propionic Acid Matrix.Biomedicines · 2021Article
- Save your gut save your age: The role of the microbiome in stem cell ageing.Journal of cellular and molecular medicine · 2019Review
- Novel Biomaterials for Tissue Engineering 2018.International journal of molecular sciences · 2018Article
- In Situ Cross-Linkable Hydrogels as a Dynamic Matrix for Tissue Regenerative Medicine.Tissue engineering and regenerative medicine · 2018Review
- Injectable Hyaluronic Acid-Materials (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Directing angiogenic differentiation of mesenchymal stem cells (MSCs) still remains challenging for successful tissue engineering. Without blood vessel formation, stem cell-based approaches are unable to fully regenerate damaged tissues due to limited support for cell viability and desired tissue/organ functionality. Herein, we report in situ cross-linkable gelatin-hydroxyphenyl propionic acid (GH) hydrogels that can induce pro-angiogenic profiles of MSCs via purely material-driven effects. This hydrogel directed endothelial differentiation of mouse and human patient-derived MSCs through integrin-mediated interactions at the cell-material interface, thereby promoting perfusable blood vessel formation in vitro and in vivo. The causative roles of specific integrin types (α₁ and α
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Registered trials
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