Evidence map›Paper›PMID 28777262›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2017

Gonorrhea and Chlamydia Case Detection Increased When Testing Increased in a Multisite US HIV Cohort, 2004-2014.

Julia R Raifman, Kelly A Gebo, William Christopher Mathews, Philip Todd Korthuis, Khalil G Ghanem, Judith A Aberg, Richard D Moore, Ank E Nijhawan, Anne K Monroe, Stephen A Berry and 1 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Sexually Transmitted Infections Treatment Guidelines, 2021.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021
    Guideline
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  7. Intersecting Epidemics: Incident Syphilis and Drug Use in Women Living With Human Immunodeficiency Virus in the United States (2005-2016).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  8. Chlamydia and Gonorrhea Incidence and Testing Among Patients in the Human Immunodeficiency Virus Outpatient Study (HOPS), 2007-2017.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Julia R Raifman*Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD; †Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; ‡Department of Medicine, University of California San Diego School of Medicine, San Diego, CA; §Department of Medicine, Oregon Health and Science University, Portland, OR; ‖Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; and ¶Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Kelly A Gebo
William Christopher Mathews
Philip Todd Korthuis
Khalil G Ghanem
Judith A Aberg
Richard D Moore
Ank E Nijhawan
Anne K Monroe
Stephen A Berry
HIV Research Network

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
North American AIDS Cohorts on Collaboration and Design (NAACCORD)U01AI069918 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Keri Nicole Althoff, RICHARD Douglas MOORE · 2006 to 2026
$65.2M
Johns Hopkins HIV Clinical CohortU01DA036935 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2014 to 2024
$14.9M
Johns Hopkins HIV Epidemiology and Prevention Sciences Training ProgramT32AI102623 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Shruti H Mehta · 2013 to 2026
$5.3M
Reducing Readmissions and Improving Outcomes in HIV-Infected PatientsK23AI112477 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI NIJHAWAN, ANK ELISABETH · 2015 to 2018
$703k
Universal Screening of HIV-Infected Persons for Gonorrhea and ChlamydiaK23AI084854 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BERRY, STEPHEN ARTHUR · 2010 to 2014
$671k
Leveraging Patient-Reported Outcomes to Improve Retention in HIV CareK23MH105284 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MONROE, ANNE KRESS · 2014 to 2016
$525k
NIAID NIH HHS K23 AI084854NIAID NIH HHS K23 AI112477NIAID NIH HHS P30 AI036214NIAID NIH HHS P30 AI094189NIAID NIH HHS T32 AI102623NIAID NIH HHS U01 AI069918NIDA NIH HHS U01 DA036935NIMH NIH HHS K23 MH105284
6 · The paper itself

Abstract

objectivesAnnual screening for gonorrhea [Neisseria gonorrhoeae (NG)] and chlamydia [Chlamydia trachomatis (CT)] is recommended for all sexually active persons living with HIV but is poorly implemented. Studies demonstrating no increases in NG and/or CT (NG/CT) case detection in clinics that successfully expanded NG/CT screening raise questions about this broad screening approach. We evaluated NG/CT case detection in the HIV Research Network during 2004-2014, a period of expanding testing.

methodsWe analyzed linear time trends in annual testing (patients tested divided by all patients in care), test positivity (patients positive divided by all tested), and case detection (the number of patients with a positive result divided by all patients in care) using multivariate repeated measures logistic regression. We determined trends overall and stratified by men who have sex with men (MSM), men who have sex exclusively with women, and women.

resultsAmong 15,614 patients (50% MSM, 26% men who have sex exclusively with women, and 24% women), annual NG/CT testing increased from 22% in 2004 to 60% in 2014 [adjusted odds ratio (AOR) per year 1.22 (1.21-1.22)]. Despite the increase in testing, test positivity also increased [AOR per year 1.10 (1.07-1.12)], and overall case detection increased from 0.8% in 2004 to 3.9% in 2014 [AOR per year 1.20 (1.17-1.22)]. Case detection was highest among MSM but increased over time among all 3 groups.

conclusionsNG/CT case detection increased as testing expanded in the population. This supports a broad approach to NG/CT screening among persons living with HIV to decrease transmission and complications of NG/CT and of HIV.

Indexed as

Mass ScreeningAdultCD4 Lymphocyte CountChlamydia InfectionsCoinfectionFemaleGonorrheaHealth PromotionHIV InfectionsHumansMaleMiddle AgedNucleic Acid Amplification TechniquesPrevalenceRisk-TakingSexual Behavior

Identifiers

PMID28777262
PMCPMC5680900

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.