Evidence map›Paper›PMID 28777161›Full record

Observational studyJournal of pediatric orthopedics. Part B2018

Lack of joint hypermobility increases the risk of surgery in adolescent idiopathic scoliosis.

Gabe Haller, Hannah Zabriskie, Shelby Spehar, Timothy Kuensting, Xavier Bledsoe, Ali Syed, Christina A Gurnett, Matthew B Dobbs

Abstract readObservational Study
In one paragraph

Observational study in Journal of pediatric orthopedics. Part B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Examination of the coexistence of scoliosis and hallux valgus in females.Acta orthopaedica et traumatologica turcica · 2025
    Article
  5. Review
  6. Observational
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Gabe HallerDepartments of Orthopaedic Surgery.
Hannah ZabriskieDepartments of Orthopaedic Surgery.
Shelby SpeharDepartments of Orthopaedic Surgery.
Timothy KuenstingDepartments of Orthopaedic Surgery.
Xavier BledsoeDepartments of Orthopaedic Surgery.
Ali SyedDepartments of Orthopaedic Surgery.
Christina A GurnettDepartments of Orthopaedic Surgery.
Matthew B DobbsDepartments of Orthopaedic Surgery.
Washington University in St. Louis · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI MOLEY, KELLE H · 2015 to 2019
$7.1M
Genetic Risk Factors for Severe ScoliosisR01AR067715 · NIAMS · WASHINGTON UNIVERSITY · PI DOBBS, MATTHEW BARRETT, GURNETT, CHRISTINA · 2015 to 2024
$6.0M
Washington University Intellectual and Developmental Disabilities Research CenterP30HD062171 · NICHD · WASHINGTON UNIVERSITY · PI CONSTANTINO, JOHN N. · 2010 to 2014
$4.3M
NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NIAMS NIH HHS R01 AR067715NICHD NIH HHS P30 HD062171NICHD NIH HHS U54 HD087011
6 · The paper itself

Abstract

Generalized joint hypermobility (GJH) is a risk factor for developing adolescent idiopathic scoliosis (AIS); however, it is not known whether joint hypermobility influences the risk of progression to surgery. Beighton joint hypermobility scores were assessed in 570 female AIS patients. Multivariate analysis was carried out to determine whether Beighton hypermobility scores were predictors of surgical intervention. In this female AIS cohort, 24.7% (141/570) had GJH (Beighton score ≥4). Multivariate analysis showed that GJH did not influence the risk of surgery, although having no joint hypermobility (Beighton score=0) increased risk (odds ratio: 1.89; P=0.003). Females who had no hypermobility (score=0) had significantly larger curves than individuals who scored at least one point on the Beighton scale [50° (interquartile range: 26) vs. 42° (interquartile range: 24), P=0.001]. Evaluation of specific measures of joint hypermobility indicated that females who could not touch their palms to the floor were 2.1-fold more likely to have surgery than patients who could perform this task (P=0.001). None of the other features measured on the Beighton score correlated with surgical risk. The lack of joint hypermobility increases the odds of surgery in females with AIS. Specifically, inability to touch the palms to the floor is an indicator of progression to surgery.

Indexed as

AdolescentCohort StudiesFemaleHumansJoint InstabilityProspective StudiesRisk FactorsScoliosis

Identifiers

PMID28777161
PMCPMC5790620
OpenAlexW2743589362

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.