Evidence map›Paper›PMID 28777120›Full record

ArticleCoronary artery disease2018

Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study: rationale and design.

Rine Nakanishi, Wendy S Post, Kazuhiro Osawa, Eranthi Jayawardena, Michael Kim, Nasim Sheidaee, Negin Nezarat, Sina Rahmani, Nicholas Kim, Nicolai Hathiramani and 9 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Coronary artery disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 1 country.

Rine NakanishiDepartment of Cardiology, Los Angeles Biomedical Research Institute.
Wendy S PostDepartment of Medicine, Division of Cardiology, Johns Hopkins Ciccarone Center for the Prevention of Heart Disease.
Kazuhiro OsawaDepartment of Cardiology, Los Angeles Biomedical Research Institute.
Eranthi JayawardenaDepartment of Cardiology, Los Angeles Biomedical Research Institute.
Michael KimDepartment of Cardiology, Los Angeles Biomedical Research Institute.
Nasim SheidaeeDepartment of Cardiology, Los Angeles Biomedical Research Institute.
Negin NezaratDepartment of Cardiology, Los Angeles Biomedical Research Institute.
Sina RahmaniDepartment of Cardiology, Los Angeles Biomedical Research Institute.
Nicholas KimDepartment of Cardiology, Los Angeles Biomedical Research Institute.
Nicolai HathiramaniDepartment of Cardiology, Los Angeles Biomedical Research Institute.
Shriraj SusarlaDepartment of Cardiology, Los Angeles Biomedical Research Institute.
Frank PalellaDepartment of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Mallory WittDepartment of HIV Medicine, Harbor-UCLA Medical Center, Torrance, California.
Michael J BlahaDepartment of Medicine, Division of Cardiology, Johns Hopkins Ciccarone Center for the Prevention of Heart Disease.
Todd T BrownDepartment of Endocrinology, Johns Hopkins School of Medicine.
Lawrence KingsleyDepartments of Infectious Diseases and Microbiology.
Sabina A HaberlenDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Christopher DailingDepartment of Cardiology, Los Angeles Biomedical Research Institute.
Matthew J BudoffDepartment of Cardiology, Los Angeles Biomedical Research Institute.
The Lundquist Institute · USJohns Hopkins University · USNorthwestern University · USUCLA Medical Center · USUniversity of Pittsburgh · US

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
University of Pittsburgh Multicenter AIDS Cohort Study (MACS)U01AI035041 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARTINSON, JEREMY JAMES, RINALDO, CHARLES R · 1993 to 2018
$71.4M
MULTICENTER AIDS COHORT STUDYU01AI035039 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLINSKY, STEVEN M · 1993 to 2018
$66.4M
Multicenter Aids Cohort Study- Part B (Baltimore Site)U01AI035042 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T, MARGOLICK, JOSEPH B. · 1993 to 2018
$61.5M
Center for the Analysis & Management of the Multicenter AIDS Cohort StudyUM1AI035043 · NIAID · JOHNS HOPKINS UNIVERSITY · PI D'SOUZA, GYPSYAMBER, JACOBSON, LISA P · 2012 to 2018
$20.7M
Subclinical Vascular Disease and Metabolic Abnormalities in MACSR01HL095129 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POST, WENDY S · 2008 to 2012
$4.9M
Progression of Coronary Atherosclerosis in MACSR01HL125053 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POST, WENDY S · 2014 to 2017
$2.9M
Ventricular Size and Valve Calcification Measures by CTR01HL071739 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI BUDOFF, MATTHEW J · 2003 to 2010
$2.0M
NCRR NIH HHS UL1 RR025005NHLBI NIH HHS R01 HL071739NHLBI NIH HHS R01 HL095129NHLBI NIH HHS R01 HL125053NIAID NIH HHS U01 AI035039NIAID NIH HHS U01 AI035041NIAID NIH HHS U01 AI035042NIAID NIH HHS UM1 AI035043
6 · The paper itself

Abstract

BACKGROUND AND

aimThe association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter study quantifying progression of coronary plaque assessed by serial coronary computed tomography angiography (CTA). PATIENTS AND

methodsHIV-infected and uninfected men who were enrolled in the Multicenter AIDS Cohort Study Cardiovascular Substudy were eligible to complete a follow-up contrast coronary CTA 3-6 years after baseline. We measured coronary plaque volume and characteristics (calcified and noncalcified plaque including fibrous, fibrous-fatty, and low attenuation) and vulnerable plaque among HIV-infected and uninfected men using semiautomated plaque software to investigate the progression of coronary atherosclerosis over time.

conclusionWe describe a novel, large prospective multicenter study investigating incidence, transition of characteristics, and progression in coronary atherosclerosis quantitatively assessed by serial coronary CTAs among HIV-infected and uninfected men.

Indexed as

Acquired Immunodeficiency SyndromeAdultAgedCase-Control StudiesCohort StudiesComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseDisease ProgressionFollow-Up StudiesHIV InfectionsHumansIncidenceMaleMiddle AgedPlaque, Atherosclerotic

Identifiers

PMID28777120
PMCPMC5722668
OpenAlexW2744021786

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.