Evidence map›Paper›PMID 28776964›Full record

ArticleCancer medicine2017

A modified Edmonton Symptom Assessment Scale for symptom clusters in radiation oncology patients.

Peter A S Johnstone, Jae Lee, Jun-Min Zhou, Zhenjun Ma, Diane Portman, Heather Jim, Hsiang-Hsuan Michael Yu

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Longitudinal patient-reported outcomes and survival among early-stage non-small cell lung cancer patients receiving stereotactic body radiotherapy.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2022
    Article
  9. Article
  10. Patient-reported outcomes: using ESAS to screen for anemia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Article
  11. Article
  12. Article
  13. Congruence of multiple patient-related outcomes within a single day.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Peter A S JohnstoneRadiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.
Jae LeeBiostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.
Jun-Min ZhouBiostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.
Zhenjun MaBiostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.
Diane PortmanSupportive Care Medicine Departments, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.
Heather JimHealth Outcomes & Behavior, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.
Hsiang-Hsuan Michael YuRadiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.ORCID http://orcid.org/0000-0002-0621-9519
Moffitt Cancer Center · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
NCI NIH HHS P30 CA076292
6 · The paper itself

Abstract

Patient-reported outcomes regarding symptom burden may provide valuable information in addition to physician assessment. Systematic collection of patient-reported outcomes may be an important metric to identify unmet needs and improve quality of patient care. To understand common symptoms of patients seen in radiation oncology clinic, we examined the prospectively collected modified Edmonton Symptom Assessment Scale (ESAS-r) data to explore symptom clusters. Our clinic established use of a modified Edmonton Symptom Assessment Scale in August 2015. All outpatients presenting for radiation oncology services completed the form at each clinic visit. Symptom clusters are defined by two or more symptoms that are interrelated and occur simultaneously with a high degree of predictability. A sample of 916 de-identified surveys was assessed statistically using principal component analysis (PCA) with varimax rotation to determine independent clustering between the symptoms queried. We found four major clusters of symptoms: Tiredness (tired, drowsiness; PC1), Loss of Appetite (nausea, lack of appetite; PC2), Low Well-Being (overall & spiritual well-being; PC3), and Depression (depression, anxiety; PC4). These accounted for 46%, 9.2%, 7.6%, and 7% of total variance, respectively. Internal consistency using Cronbach's alpha was 0.87, 0.7, 0.82, and 0.87, respectively. The most frequent write-in item was itchiness, present in 24% of the 148 patients responding. Assessment of patients seen in a large radiation oncology clinic revealed several symptom clusters. {Tiredness and drowsiness} represents a major symptom cluster. Itchiness may be underrecognized.

Indexed as

AdultAgedAged, 80 and overAnxietyDepressionFatigueFemaleHumansMaleMiddle AgedPatient Reported Outcome MeasuresPrincipal Component AnalysisRadiation OncologySymptom AssessmentYoung AdultESASpatient-reported outcomesradiation oncologysymptom clusterssymptom management

Identifiers

PMID28776964
PMCPMC5603842
OpenAlexW2742362483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.