Evidence map›Paper›PMID 28776930›Full record

Trial reportEarly intervention in psychiatry2019

Early intervention for youth at high risk for bipolar disorder: A multisite randomized trial of family-focused treatment.

David J Miklowitz, Christopher D Schneck, Patricia D Walshaw, Amy S Garrett, Manpreet K Singh, Catherine A Sugar, Kiki D Chang

Abstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Early intervention in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Family communication with teens at clinical high-risk for psychosis or bipolar disorder.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2018
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  7. Review
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  11. Generalizing the Prediction of Bipolar Disorder Onset Across High-Risk Populations.Journal of the American Academy of Child and Adolescent Psychiatry · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David J MiklowitzLos Angeles (UCLA) Semel Institute, University of California, Los Angeles, California.
Christopher D SchneckDepartment of Psychiatry, University of Colorado Denver School of Medicine, Aurora, Colorado.
Patricia D WalshawLos Angeles (UCLA) Semel Institute, University of California, Los Angeles, California.
Amy S GarrettPsychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.
Manpreet K SinghPsychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.
Catherine A SugarLos Angeles (UCLA) Semel Institute, University of California, Los Angeles, California.
Kiki D ChangPsychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.

Funding

1/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2016
$3.6M
2/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093666 · NIMH · STANFORD UNIVERSITY · PI HARDAN, ANTONIO · 2012 to 2016
$2.0M
Family-Focused Treatment for Youth with Early-Onset Bipolar or Psychotic DisorderR21MH097007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2013
$439k
NIMH NIH HHS MH093666NIMH NIH HHS MH093676NIMH NIH HHS R01 MH093666NIMH NIH HHS R01 MH093676NIMH NIH HHS R21 MH097007
6 · The paper itself

Abstract

aimsDespite the considerable public health impact of bipolar disorder (BD), no psychosocial interventions have been systematically evaluated in its early prodromal stages. We describe the rationale, design and analytic methods for a 3-site randomized trial of family-focused treatment for youth at high risk (FFT-HR) for BD.

methodsParticipants (ages 9-17 years) have a diagnosis of unspecified BD or major depressive disorder, current mood symptoms and at least one first- or second-degree relative with a lifetime history of BD I or II. Participants are randomly assigned to FFT-HR (12 sessions in 4 months of family psychoeducation and skills training) or enhanced care (EC; 6 individual and family sessions over 4 months), with pharmacotherapy provided as needed. A subset of participants undergo pre- and post-treatment functional MRI (fMRI) scans while performing face-rating and family problem-solving tasks designed to activate corticolimbic circuitry. Independent evaluators assess participants' status every 4 to 6 months for up to 4 years.

resultsWe hypothesize that FFT-HR will be more effective than EC in reducing the severity of mood symptoms (primary outcome) and the hazard of a first manic episode (secondary) over 4 years. Secondarily, we will explore whether FFT-HR is associated with greater decreases in amygdala activation and increases in dorsolateral, ventrolateral or anterior medial prefrontal cortex activation from pre- to post-treatment. Clinical characteristics of 133 subjects enrolled at baseline are described.

conclusionsThis study will test a novel intervention to reduce the early symptoms of BD, and identify neural and behavioural mechanisms that may help refine future treatments.

Indexed as

AdolescentBipolar DisorderChildCombined Modality TherapyFamily TherapyFemaleHumansMajor Depressive DisorderMalePatient Education as TopicProblem SolvingProdromal SymptomsPsychotropic DrugsRisk AssessmentTreatment OutcomePsychotropic Drugsexpressed emotionfamily therapymanianeuroimagingprodromal

Identifiers

PMID28776930
PMCPMC5797511

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.