ArticleJournal of the Royal Society of Medicine2017
The history and development of N-of-1 trials.
Article in Journal of the Royal Society of Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06721871 (Evaluation of Safety, Tolerability and Efficacy of Crofelemer Following Multiple Ascending Doses of Crofelemer Powder for Oral Solution in Pediatric Participants With Microvillus Inclusion Disease), which is not on this map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Safety, Tolerability and Efficacy of Crofelemer Following Multiple Ascending Doses of Crofelemer Powder for Oral Solution in Pediatric Participants With Microvillus Inclusion Disease (MVID)
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Personalized (N-of-1) Trials for Depression: A Systematic Review.Journal of clinical psychopharmacology · 2018Pooled it
- Acupressure and hypnosis in arterial hypertension: a series of N-of-1 trials.Frontiers in medicine · 2026Trial
- The Diagnostic Elimination Diet and Challenge Protocol for Management of Patients with Food Intolerance-Purpose and Development.Nutrients · 2026Article
- Mobile App-Based Tracking of Daily Explicit and Implicit Sense of Agency Among Adults Living in Japan: Longitudinal Observational Study.JMIR formative research · 2026Observational
- Digital N-of-1 trials and their application in experimental physiology.Experimental physiology · 2026Review
- Individual-centric N-of-1 trials: a case study assessing the effect of alcohol abstinence on mood levels.BMC medical research methodology · 2026Article
- Observation Oriented Modeling: Principles and Tools for Person-Oriented Research.Journal for person-oriented research · 2026Article
- Treatment of Anxiety in Athletes Using Cognitive Behavioral Therapy: A Single-Case Experimental Design with Multiple Baselines.Journal for person-oriented research · 2026Article
- A visualization tool for individual gene expression profiles among males and females in GTEx tissues.Biology of sex differences · 2025Article
- When there is little or no research evidence: a clinical decision tool.The Journal of the Canadian Chiropractic Association · 2025Article
- Blueprint for clinical N-of-1 strategies with off-label precision treatments in monogenic epilepsies.Orphanet journal of rare diseases · 2025Review
- Precision therapies for genetic epilepsies in 2025: Promises and pitfalls.Epilepsia open · 2025Article
- N-of-1 tests in general practice: pharmacological considerations.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025Article
- A conceptual model and practical guidance for the development, administration, and evaluation of individualized therapies.Frontiers in medicine · 2025Article
- A qualitative study on the facilitators and barriers to adopting the N-of-1 trial methodology as part of clinical practice: potential versus implementation challenges.International journal of qualitative studies on health and well-being · 2024Article
- The role of single case experimental designs in evidence creation in rehabilitation.European journal of physical and rehabilitation medicine · 2024Article
- Uncovering individualised treatment effects for educational trials.Scientific reports · 2024Article
- A methodological review of randomised n-of-1 trials.Trials · 2024Review
- Analyzing population-level trials as N-of-1 trials: An application to gait.Contemporary clinical trials communications · 2024Article
- THE VALUE OF N-OF-1 DATA IN ZOOLOGICAL MEDICINE: A METHODOLOGICAL REVIEW.Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.