ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2019
A combined static-dynamic single-dose imaging protocol to compare quantitative dynamic SPECT with static conventional SPECT.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Cross-institutional validation of a polar map-free 3D deep learning model for obstructive coronary artery disease prediction using myocardial perfusion imaging: insights into generalizability and bias.European journal of nuclear medicine and molecular imaging · 2025Article
- Utility of myocardial blood flow assessment with dynamic CZT single photon emission computed tomography in patients with myocardial bridging: Is this 'wishful thinking' in this dynamic situation?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Left ventricular mechanical dyssnchrony: A potential new marker for 3-vessel CAD.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Monte Carlo Simulation and Reconstruction: Assessment of Myocardial Perfusion Imaging of Tracer Dynamics With Cardiac Motion Due to Deformation and Respiration Using Gamma Camera With Continuous Acquisition.Frontiers in cardiovascular medicine · 2022Article
- The Importance of Time-of-Flight Reconstruction and Point Spread Modeling in the Measurement of Myocardial Blood Flow Parameters.Current cardiology reports · 2021Review
- Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2019: Single-photon emission computed tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Review
- SPECT quantification of myocardial blood flow: A journey of a thousand miles begins with a single step (Lao Tzu, Chinese philosopher, 604-531 BC).Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Comparison of sparse domain approaches for 4D SPECT dynamic image reconstruction.Medical physics · 2018Article
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Abstract
backgroundSPECT myocardial perfusion imaging (MPI) is a clinical mainstay that is typically performed with static imaging protocols and visually or semi-quantitatively assessed for perfusion defects based upon the relative intensity of myocardial regions. Dynamic cardiac SPECT presents a new imaging technique based on time-varying information of radiotracer distribution, which permits the evaluation of regional myocardial blood flow (MBF) and coronary flow reserve (CFR). In this work, a preliminary feasibility study was conducted in a small patient sample designed to implement a unique combined static-dynamic single-dose one-day visit imaging protocol to compare quantitative dynamic SPECT with static conventional SPECT for improving the diagnosis of coronary artery disease (CAD).
methodsFifteen patients (11 males, four females, mean age 71 ± 9 years) were enrolled for a combined dynamic and static SPECT (Infinia Hawkeye 4, GE Healthcare) imaging protocol with a single dose of
resultsOverall, conventional static SPECT was normal in ten patients and abnormal in five patients, dynamic SPECT was normal in 12 patients and abnormal in three patients, and CFR from dynamic SPECT was normal in nine patients and abnormal in six patients. Among those 11 patients with SCA, conventional SPECT was normal in 5, 3 with documented CAD on SCA with an overall accuracy of 64%, sensitivity of 40% and specificity of 83%. Dynamic SPECT image analysis also produced a similar accuracy, sensitivity, and specificity. CFR was normal in 6, each with CAD on SCA with an overall accuracy of 91%, sensitivity of 80%, and specificity of 100%. The mean CFR was significantly lower for SCA detected abnormal than for normal patients (3.86±1.06 vs 1.94±0. 0.67, P < 0.001).
conclusionsThe visually assessed image findings in static and dynamic SPECT are subjective, and may not reflect direct physiologic measures of coronary lesion based on SCA. The CFR measured with dynamic SPECT is fully objective, with better sensitivity and specificity, available only with the data generated from the dynamic SPECT method.
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