Evidence map›Paper›PMID 28776290›Full record

ArticleInvestigational new drugs2017

Synthesis, characterization, and evaluation of Cd[L-proline]

Anusha Chidambaram, Arunachalam Sekar, Kavya S H, Ramesh Kumar Chidambaram, Kalaiarasi Arunachalam, Senthilkumar G P, Ravikumar Vilwanathan

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Investigational new drugs, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 15 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Anusha ChidambaramDepartment of Biochemistry, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 620 024, Tamil Nadu, India.
Arunachalam SekarDepartment of Biotechnology, School of Biotechnology, Bharathidasan University, Tiruchirappalli, 620 024, Tamil Nadu, India.
Kavya S HOrganic Chemistry Laboratory, Department of Chemistry, Veltech University, Avadi, Chennai, 600 062, Tamil Nadu, India.
Ramesh Kumar ChidambaramOrganic Chemistry Laboratory, Department of Chemistry, Veltech University, Avadi, Chennai, 600 062, Tamil Nadu, India. nscrameshkumar@gmail.com.
Kalaiarasi ArunachalamDepartment of Biochemistry, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 620 024, Tamil Nadu, India.
Senthilkumar G PDepartment of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605 006, Tamil Nadu, India.
Ravikumar VilwanathanDepartment of Biochemistry, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 620 024, Tamil Nadu, India. ravikumarbdu@gmail.com.
Bharathidasan University · INJawaharlal Institute of Post Graduate Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histone deacetylases (HDACs) play an important role in the epigenetic regulation of gene expression through their effects on the compact chromatin structure. In clinical studies, several classes of histone deacetylase inhibitors (HDACi) have demonstrated potent anticancer activities with metal complexes. Hence, we synthesized cadmium-proline complexes using both the D- and L-isomers of proline and evaluated their biological activities by observing the efficiency of their inhibition of HDAC activity, ability to reduce the expression of HDAC isoforms in A549 cells and effect on apoptosis. The synthesized compounds were characterized by UV, IR, NMR spectroscopy and elemental analysis. In-vitro cell toxicity was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, and the 50% inhibitory concentration (IC

Indexed as

Epigenesis, GeneticA549 CellsAcetylationApoptosisCadmium CompoundsCell Cycle CheckpointsHistone Deacetylase 1Histone Deacetylase InhibitorsHumansIsoenzymesProlineCadmium CompoundsHDAC1 protein, humanHistone Deacetylase 1Histone Deacetylase InhibitorsIsoenzymesProlineAmino acidsApoptosisEpigeneticsHDAC inhibitorHyperacetylationMetal complexes

Identifiers

PMID28776290
OpenAlexW2745013699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.