ArticleBrain structure & function2018
Regulator of G protein signaling 14 (RGS14) is expressed pre- and postsynaptically in neurons of hippocampus, basal ganglia, and amygdala of monkey and human brain.
Article in Brain structure & function, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04865198 (Role of Neuralized1 and RGS14 Genes With ASD Patients), which is not on this map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Neuralized1 and RGS14 Genes With ASD Patients
Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Spatial statistics and point pattern analysis reveal lifespan trajectories of microglial density and clustering in the primate hippocampus.Scientific reports · 2026Article
- Regulator of G protein signalling 14 (RGS14) protein expression profile in the adult mouse brain.The European journal of neuroscience · 2024Article
- Identification of hippocampal area CA2 in hamster and vole brain.The Journal of comparative neurology · 2024Article
- Identification of hippocampal area CA2 in hamster and vole brain.bioRxiv : the preprint server for biology · 2024Article
- RGS14 limits seizure-induced mitochondrial oxidative stress and pathology in hippocampus.Neurobiology of disease · 2023Article
- Mechanisms of mGluR-dependent plasticity in hippocampal area CA2.Hippocampus · 2023Article
- Defining hippocampal area CA2 in the fox (Vulpes vulpes) brain.Hippocampus · 2023Article
- RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease.Hippocampus · 2023Review
- RGS14 is neuroprotective against seizure-induced mitochondrial oxidative stress and pathology in hippocampus.bioRxiv : the preprint server for biology · 2023Article
- Machine learning-based segmentation of the rodent hippocampal CA2 area from Nissl-stained sections.Frontiers in neuroanatomy · 2023Article
- Phenotype and genotype in a Taiwanese girl with Sotos Syndrome.BioMedicine · 2022Article
- RGS14 modulates locomotor behavior and ERK signaling induced by environmental novelty and cocaine within discrete limbic structures.Psychopharmacology · 2021Article
- Perineuronal net degradation rescues CA2 plasticity in a mouse model of Rett syndrome.The Journal of clinical investigation · 2021Article
- RGS14 Regulation of Post-Synaptic Signaling and Spine Plasticity in Brain.International journal of molecular sciences · 2021Review
- Prelimbic cortical targets of ventromedial thalamic projections include inhibitory interneurons and corticostriatal pyramidal neurons in the rat.Brain structure & function · 2020Article
- Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis.Acta neuropathologica communications · 2019Article
- Specific Proteomes of Hippocampal Regions CA2 and CA1 Reveal Proteins Linked to the Unique Physiology of Area CA2.Journal of proteome research · 2019Article
- 14-3-3γ binds regulator of G protein signaling 14 (RGS14) at distinct sites to inhibit the RGS14:GαThe Journal of biological chemistry · 2018Article
- Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and Disease.Pharmacological reviews · 2018Review
- Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (CaJournal of proteome research · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Regulator of G protein signaling 14 (RGS14) is a multifunctional signaling protein primarily expressed in mouse pyramidal neurons of hippocampal area CA2 where it regulates synaptic plasticity important for learning and memory. However, very little is known about RGS14 protein expression in the primate brain. Here, we validate the specificity of a new polyclonal RGS14 antibody that recognizes not only full-length RGS14 protein in primate, but also lower molecular weight forms of RGS14 protein matching previously predicted human splice variants. These putative RGS14 variants along with full-length RGS14 are expressed in the primate striatum. By contrast, only full-length RGS14 is expressed in hippocampus, and shorter variants are completely absent in rodent brain. We report that RGS14 protein immunoreactivity is found both pre- and postsynaptically in multiple neuron populations throughout hippocampal area CA1 and CA2, caudate nucleus, putamen, globus pallidus, substantia nigra, and amygdala in adult rhesus monkeys. A similar cellular expression pattern of RGS14 in the monkey striatum and hippocampus was further confirmed in humans. Our electron microscopy data show for the first time that RGS14 immunostaining localizes within nuclei of striatal neurons in monkeys. Taken together, these findings suggest new pre- and postsynaptic regulatory functions of RGS14 and RGS14 variants, specific to the primate brain, and provide evidence for unconventional roles of RGS14 in the nuclei of striatal neurons potentially important for human neurophysiology and disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.