Evidence map›Paper›PMID 28776088›Full record

SynthesisEuropean journal of nuclear medicine and molecular imaging2017

Impact of partial-volume correction in oncological PET studies: a systematic review and meta-analysis.

Matthijs C F Cysouw, Gerbrand M Kramer, Linda J Schoonmade, Ronald Boellaard, Henrica C W de Vet, Otto S Hoekstra

Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in European journal of nuclear medicine and molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. IntegratedEuropean journal of nuclear medicine and molecular imaging · 2018
    Trial
  4. Review
  5. Article
  6. Review
  7. The role ofAbdominal radiology (New York) · 2026
    Article
  8. The correlation between FDG-PET metabolic parameters, PD-L1 expression and p16/HPV status in oropharyngeal cancers.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  9. Article
  10. Review
  11. Physiological bio-distribution ofAnnals of nuclear medicine · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Matthijs C F CysouwDepartment of Radiology and Nuclear Medicine, VU University Medical Centre, P.O. Box 7057, 1007 MB, Amsterdam, Netherlands.
Gerbrand M KramerDepartment of Radiology and Nuclear Medicine, VU University Medical Centre, P.O. Box 7057, 1007 MB, Amsterdam, Netherlands.
Linda J SchoonmadeDepartment of Medical Library, VU University Medical Centre, Amsterdam, Netherlands.
Ronald BoellaardDepartment of Radiology and Nuclear Medicine, VU University Medical Centre, P.O. Box 7057, 1007 MB, Amsterdam, Netherlands.
Henrica C W de VetDepartment of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, Netherlands.
Otto S HoekstraDepartment of Radiology and Nuclear Medicine, VU University Medical Centre, P.O. Box 7057, 1007 MB, Amsterdam, Netherlands. os.hoekstra@vumc.nl.
Amsterdam UMC Location VUmc · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePositron-emission tomography can be useful in oncology for diagnosis, (re)staging, determining prognosis, and response assessment. However, partial-volume effects hamper accurate quantification of lesions <2-3× the PET system's spatial resolution, and the clinical impact of this is not evident. This systematic review provides an up-to-date overview of studies investigating the impact of partial-volume correction (PVC) in oncological PET studies.

methodsWe searched in PubMed and Embase databases according to the PRISMA statement, including studies from inception till May 9, 2016. Two reviewers independently screened all abstracts and eligible full-text articles and performed quality assessment according to QUADAS-2 and QUIPS criteria. For a set of similar diagnostic studies, we statistically pooled the results using bivariate meta-regression.

resultsThirty-one studies were eligible for inclusion. Overall, study quality was good. For diagnosis and nodal staging, PVC yielded a strong trend of increased sensitivity at expense of specificity. Meta-analysis of six studies investigating diagnosis of pulmonary nodules (679 lesions) showed no significant change in diagnostic accuracy after PVC (p = 0.222). Prognostication was not improved for non-small cell lung cancer and esophageal cancer, whereas it did improve for head and neck cancer. Response assessment was not improved by PVC for (locally advanced) breast cancer or rectal cancer, and it worsened in metastatic colorectal cancer.

conclusionsThe accumulated evidence to date does not support routine application of PVC in standard clinical PET practice. Consensus on the preferred PVC methodology in oncological PET should be reached. Partial-volume-corrected data should be used as adjuncts to, but not yet replacement for, uncorrected data.

Indexed as

HumansNeoplasmsNeoplasm StagingPositron-Emission TomographyOncologyPartial-volume correctionPartial-volume effectPetQuantification

Identifiers

PMID28776088
PMCPMC5656693
OpenAlexW2744831393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.