Evidence map›Paper›PMID 28776023›Full record

ArticleACS central science2017

Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors.

Hung V-T Nguyen, Qixian Chen, Joseph T Paletta, Peter Harvey, Yivan Jiang, Hui Zhang, Michael D Boska, M Francesca Ottaviani, Alan Jasanoff, Andrzej Rajca and 1 more

Abstract read
In one paragraph

Article in ACS central science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. ACS macro letters · 2025
    Article
  9. Article
  10. Article
  11. Contrast Agents Based on Human Serum Albumin and Nitroxides forInternational journal of molecular sciences · 2024
    Article
  12. Article
  13. Article
  14. Synthesis of Bottlebrush Polymers byJournal of the American Chemical Society · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. High-SpinJournal of the American Chemical Society · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hung V-T NguyenDepartment of Chemistry, Department of Biological Engineering, Department of Brain and Cognitive Sciences, and Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Qixian ChenDepartment of Chemistry, Department of Biological Engineering, Department of Brain and Cognitive Sciences, and Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Joseph T PalettaDepartment of Chemistry, University of Nebraska, Lincoln, Nebraska 68588, United States.
Peter HarveyDepartment of Chemistry, Department of Biological Engineering, Department of Brain and Cognitive Sciences, and Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Yivan JiangDepartment of Chemistry, Department of Biological Engineering, Department of Brain and Cognitive Sciences, and Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Hui ZhangDepartment of Chemistry, University of Nebraska, Lincoln, Nebraska 68588, United States.
Michael D BoskaDepartment of Radiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
M Francesca OttavianiDepartment of Pure and Applied Sciences, University of Urbino, Urbino 61029, Italy.
Alan JasanoffDepartment of Chemistry, Department of Biological Engineering, Department of Brain and Cognitive Sciences, and Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Andrzej RajcaDepartment of Chemistry, University of Nebraska, Lincoln, Nebraska 68588, United States.
Jeremiah A JohnsonDepartment of Chemistry, Department of Biological Engineering, Department of Brain and Cognitive Sciences, and Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MATTHEW G. VANDER HEIDEN · 1985 to 2026
$93.9M
Organic nanoparticles for dual MRI-guided therapeutic selection and ovarian cancer drug deliveryR01CA220468 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Jeremiah Allen Johnson · 2017 to 2026
$4.9M
Synthesis of Metal-Free Magnetic Resonance Imaging Contrast AgentsR01EB019950 · NIBIB · UNIVERSITY OF NEBRASKA LINCOLN · PI RAJCA, ANDRZEJ · 2015 to 2018
$1.2M
Calcium sensors for molecular fMRIU01NS090451 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JASANOFF, ALAN · 2014 to 2016
$1.1M
PEG-Branch-Nitroxide Nanostructured Organic MRI Contrast AgentsR21EB018529 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JOHNSON, JEREMIAH ALLEN · 2014 to 2015
$392k
NCI NIH HHS P30 CA014051NCI NIH HHS R01 CA220468NIBIB NIH HHS R01 EB019950NIBIB NIH HHS R21 EB018529NINDS NIH HHS U01 NS090451Wellcome Trust
6 · The paper itself

Abstract

Metal-free magnetic resonance imaging (MRI) agents could overcome the established toxicity associated with metal-based agents in some patient populations and enable new modes of functional MRI

Identifiers

PMID28776023
PMCPMC5532724

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.