Evidence map›Paper›PMID 28775785›Full record

ArticleJournal of Cancer2017

Lovastatin Inhibits Cancer Stem Cells and Sensitizes to Chemo- and Photodynamic Therapy in Nasopharyngeal Carcinoma.

Yikun Peng, Guangchun He, Da Tang, Li Xiong, Yu Wen, Xiongying Miao, Zhangyong Hong, Hui Yao, Chao Chen, Shichao Yan and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
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  8. Review
  9. Atorvastatin inhibits the proliferation of MKN45-derived gastric cancer stem cells in a mevalonate pathway-independent manner.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022
    Article
  10. Article
  11. Repurposing of Anticancer Stem Cell Drugs in Brain Tumors.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021
    Review
  12. Review
  13. Article
  14. Statins: a repurposed drug to fight cancer.Journal of experimental & clinical cancer research : CR · 2021
    Review
  15. Article
  16. Review
  17. Lipid composition of the cancer cell membrane.Journal of bioenergetics and biomembranes · 2020
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Yikun PengDepartment of Otorhinolaryngology-Head and Neck Surgery, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.
Guangchun HeMedical College, Hunan Normal University, Changsha, Hunan, China.
Da TangDepartment of General Surgery, Second Xiangya Hospital, Central South University, Changsha, China.
Li XiongDepartment of General Surgery, Second Xiangya Hospital, Central South University, Changsha, China.
Yu WenDepartment of General Surgery, Second Xiangya Hospital, Central South University, Changsha, China.
Xiongying MiaoDepartment of General Surgery, Second Xiangya Hospital, Central South University, Changsha, China.
Zhangyong HongState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China.
Hui YaoMedical College, Hunan Normal University, Changsha, Hunan, China.
Chao ChenMedical College, Hunan Normal University, Changsha, Hunan, China.
Shichao YanMedical College, Hunan Normal University, Changsha, Hunan, China.
Lu LuMedical College, Hunan Normal University, Changsha, Hunan, China.
Yingke YangCollege of Biology, Hunan University, Changsha, Hunan 410082, China.
Qinglong LiDepartment of General Surgery, Second Xiangya Hospital, Central South University, Changsha, China.
Xiyun DengMedical College, Hunan Normal University, Changsha, Hunan, China.
Hunan Normal University · CNCentral South University · CNGuizhou Provincial People's Hospital · CNHunan University · CNNankai University · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus-associated malignancy occurring at high incidence in Southeast Asia and southern China. In spite of the good response to radio- and chemo-therapy at the early stage, resistance and recurrence develop in NPC patients in the advanced setting. Cancer stem cells (CSCs) play an important role in drug resistance and cancer recurrence. Here we report that lovastatin, a natural compound and a lipophilic statin that has already been used in the clinic to treat hypercholesterolemia, inhibited the CSC properties and induced apoptosis and cell cycle arrest in sphere-forming cells derived from the 5-8F and 6-10B NPC cell lines. Furthermore, lovastatin conferred enhanced sensitivity to the chemotherapeutic and photodynamic agents in NPC CSCs. Together our findings suggest that targeting CSCs by lovastatin in combination with routine chemotherapeutic drugs or photodynamic therapy might be a promising approach to the treatment of NPC.

Indexed as

Cancer stem cellsChemotherapyLovastatinNasopharyngeal carcinomaPhotodynamic therapy.

Identifiers

PMID28775785
PMCPMC5535721
OpenAlexW2623121460

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.