ArticleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2017
Expression of intelectin-1 in bronchial epithelial cells of asthma is correlated with T-helper 2 (Type-2) related parameters and its function.
Article in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Intelectin-2 is a broad-spectrum antimicrobial lectin.Nature communications · 2026Article
- Exploring the role of intelectin-1 in modulating asthma through the gut-bone-lung axis.Gut microbes · 2025Article
- SARS-CoV-2 infection results in a unique lung proteome long after virus resolution in the hamster.Npj viruses · 2024Article
- A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma.Nature communications · 2024Article
- Human Intelectin-1 (hITL-1) as Modulator of Metabolic Syndrome (MetS): AnJournal of pharmacy & bioallied sciences · 2024Article
- The Role of Peptides in Asthma-Obesity Phenotype.International journal of molecular sciences · 2024Review
- Molecular analysis of duodenal eosinophilia.The Journal of allergy and clinical immunology · 2023Article
- Gut Microbial Perturbation and Host Response Induce Redox Pathway Upregulation along the Gut-Liver Axis during Giardiasis in C57BL/6J Mouse Model.International journal of molecular sciences · 2023Article
- Identifying key genes and functionally enriched pathways in Th2-high asthma by weighted gene co-expression network analysis.BMC medical genomics · 2022Article
- Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor.Bioactive materials · 2022Article
- Adiponectin and Asthma: Knowns, Unknowns and Controversies.International journal of molecular sciences · 2021Review
- Human intelectin-1 (ITLN1) genetic variation and intestinal expression.Scientific reports · 2021Article
- Real-life effectiveness of fluticasone furoate/vilanterol after switching from fluticasone/salmeterol or budesonide/formoterol therapy in patients with symptomatic asthma: Relvar Ellipta for Real Asthma Control Study (RERACS study).Journal of thoracic disease · 2020Article
- Pulmonary Innate Immune Response Determines the Outcome of Inflammation During Pneumonia and Sepsis-Associated Acute Lung Injury.Frontiers in immunology · 2020Review
- Comparison of inducible nitric oxide synthase mRNA expression in different airway portions and association with nitric oxide parameters from patients with asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Article
- Elevated Levels of Intelectin-1, a Pathogen-binding Lectin, in the BAL Fluid of Patients with Chronic Eosinophilic Pneumonia and Hypersensitivity Pneumonitis.Internal medicine (Tokyo, Japan) · 2018Article
- Inhibition of C-X-C Motif Chemokine 10 (CXCL10) Protects Mice from Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntelectin-1 (ITLN-1) is secreted by intestinal goblet cells and detectable in blood. Its expression is increased in IL-13-overexpressing mouse airways. However, its expression and function in human airways is poorly understood.
methodsDistal and proximal bronchial epithelial cells (BECs) were isolated from bronchoscopic brushings of disease control (D-CON), COPD, inhaled corticosteroid-treated asthma (ST-Asthma) and inhaled corticosteroid-naïve asthma (SN-Asthma) patients.
results
conclusionITLN-1 is induced by IL-13 and expressed mainly in goblet cells in untreated asthma where its levels correlate with known Type-2 related parameters. Further, ITLN-1 inhibits Type-1 chemokine expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.