ArticleScientific reports2017
High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- A new and more effective feticide technique in late termination of pregnancy: potassium chloride injection into the interventricular septum of the fetal heart.Archives of gynecology and obstetrics · 2023Trial
- Histology-validated quantitative MRI characterization of collagen-rich Purkinje fiber-associated pathways in the ex vivo porcine heart.European radiology experimental · 2026Article
- Computational Modelling of Selective Capture Mechanisms in Conduction System Pacing.Annals of biomedical engineering · 2026Article
- Structural Characterization of Cardiac Free-Running Purkinje Fibers Using Inhomogeneous Magnetization Transfer (ihMT): A Proof of Concept MRI-Histology Approach.NMR in biomedicine · 2026Article
- Computational analysis of intracardiac collision risk and optimal site for right ventricular leadless left bundle branch area pacing: A simulation study.Heart rhythm O2 · 2026Article
- Effects of Purkinje Fiber Conduction Block on Cardiac Pump Function: Computational Modeling Study.Bioengineering (Basel, Switzerland) · 2026Article
- Anatomic complexities of the human right ventricle: Considerations for clinical practice in the electrophysiology laboratory.Heart rhythm O2 · 2026Review
- Resynchronisation efficacy of pacing strategies depends on the assessment metric: a computational study.Frontiers in physiology · 2026Article
- Mechanistic interpretations of sustained ventricular fibrillation: The role of mapping methodology, model and time.Heart international · 2026Review
- Sinoatrial Node Dynamics: Clinical Relevance and microRNA-Based Modulation of Pacemaker Activity.Cureus · 2025Review
- To reconnect or not reconnect distal Purkinje fibers, that is the question when modeling the Purkinje fiber network.Frontiers in physiology · 2025Article
- High-resolution 3D visualization of human hearts with emphases on the cardiac conduction system components-a new platform for medical education, mix/virtual reality, computational simulation.Frontiers in medicine · 2025Article
- High-fidelity 3D models of human cadavers and their organs with the use of handheld scanner-Alternative method in medical education and clinical practice.Frontiers in medicine · 2025Article
- Editorial: The architecture of the human sinus node.Frontiers in medicine · 2025Article
- Cryo-X-Ray Phase Contrast Imaging Enables Combined 3D Structural Quantification and Nucleic Acid Analysis of Myocardial Biopsies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Profiling Reduced Expression of Contractile and Mitochondrial mRNAs in the Human Sinoatrial Node vs. Right Atrium and Predicting Their Suppressed Expression by Transcription Factors and/or microRNAs.International journal of molecular sciences · 2024Article
- Current Role of Conduction System Pacing in Patients Requiring Permanent Pacing.Korean circulation journal · 2024Review
- GWAS advancements to investigate disease associations and biological mechanisms.Clinical and translational discovery · 2024Article
- Cardiac conduction diseases: understanding the molecular mechanisms to uncover targets for future treatments.Expert opinion on therapeutic targets · 2024Review
- Interactive teaching of medical 3D cardiac anatomy: atrial anatomy enhanced by ECG and 3D visualization.Frontiers in medicine · 2024Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac arrhythmias and conduction disturbances are accompanied by structural remodelling of the specialised cardiomyocytes known collectively as the cardiac conduction system. Here, using contrast enhanced micro-computed tomography, we present, in attitudinally appropriate fashion, the first 3-dimensional representations of the cardiac conduction system within the intact human heart. We show that cardiomyocyte orientation can be extracted from these datasets at spatial resolutions approaching the single cell. These data show that commonly accepted anatomical representations are oversimplified. We have incorporated the high-resolution anatomical data into mathematical simulations of cardiac electrical depolarisation. The data presented should have multidisciplinary impact. Since the rate of depolarisation is dictated by cardiac microstructure, and the precise orientation of the cardiomyocytes, our data should improve the fidelity of mathematical models. By showing the precise 3-dimensional relationships between the cardiac conduction system and surrounding structures, we provide new insights relevant to valvar replacement surgery and ablation therapies. We also offer a practical method for investigation of remodelling in disease, and thus, virtual pathology and archiving. Such data presented as 3D images or 3D printed models, will inform discussions between medical teams and their patients, and aid the education of medical and surgical trainees.
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