Evidence map›Paper›PMID 28775376›Full record

ArticleInternational journal of obesity (2005)2017

Altered circadian feeding behavior and improvement of metabolic syndrome in obese Tac1-deficient mice.

C A Maguire, S León, R S Carroll, U B Kaiser, V M Navarro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Congenital ablation ofAmerican journal of physiology. Endocrinology and metabolism · 2021
    Article
  4. Article
  5. Kisspeptin and Metabolism: The Brain and Beyond.Frontiers in endocrinology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

C A MaguireDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
S LeónDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
R S CarrollDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
U B KaiserDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
V M NavarroDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Harvard University · USBrigham and Women's Hospital · US

Funding

The Genetic Determinants of Human GNRH DeficiencyU54HD028138 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI CROWLEY, WILLIAM FRANCIS · 2000 to 2013
$19.9M
Deciphering the functional role of MKRN3 in puberty and reproductionR01HD082314 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI Ursula B. Kaiser · 2015 to 2026
$5.7M
REPRODUCTIVE PHYSIOLOGY OF LUTROPIN SYNTHESISR01HD019938 · NICHD · JOSLIN DIABETES CENTER · PI KAISER, URSULA B. · 1985 to 2017
$3.9M
The Kiss1 system in the neuroendocrine control of reproductionR00HD071970 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI NAVARRO, VICTOR MANUEL · 2015 to 2017
$746k
The Kiss1 system in the neuroendocrine control of reproductionK99HD071970 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI NAVARRO, VICTOR MANUEL · 2013 to 2014
$274k
NICHD NIH HHS K99 HD071970NICHD NIH HHS R00 HD071970NICHD NIH HHS R01 HD019938NICHD NIH HHS R01 HD082314NICHD NIH HHS U54 HD028138
6 · The paper itself

Abstract

backgroundMetabolic function is regulated by the interplay of central and peripheral factors that ultimately regulate food intake (FI) and energy expenditure. The tachykinin substance P (SP) has been identified as a novel regulator of energy balance, however, the mechanisms underlying this effect are ill-defined and conflicting data regarding the role of SP on FI have been reported by different groups.

objectiveTo further characterize the metabolic role of the Tac1 gene products (SP and neurokinin A) in mice through a series of genetic, metabolic and behavioral studies in Tac1-deficient mice.

resultsTac1

conclusionsThese results provide further evidence that Tac1 controls circadian feeding behavior and metabolism in mice through mechanisms that involve the regulation of the melanocortin system. In addition, these studies suggest that the blockade of SP may offer a new method to treat metabolic syndrome.

Indexed as

AnimalsCircadian RhythmDisease Models, AnimalEnergy MetabolismFeeding BehaviorMetabolic SyndromeMiceMice, KnockoutMice, ObeseNeurokinin-1 Receptor AntagonistsReceptors, Neurokinin-1Signal TransductionSubstance PTachykininsNeurokinin-1 Receptor AntagonistsReceptors, Neurokinin-1Substance PTachykinins

Identifiers

PMID28775376
PMCPMC5716839
OpenAlexW2743976411

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.