Evidence map›Paper›PMID 28775375›Full record

Observational studyInternational journal of obesity (2005)2017

The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study.

V T Boyle, E B Thorstensen, J M D Thompson, L M E McCowan, E A Mitchell, K M Godfrey, L Poston, C R Wall, R Murphy, W Cutfield and 3 more

Open access · greenAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Vitamin D and childhood asthma: causation and contribution to disease activity.Current opinion in allergy and clinical immunology · 2019
    Review
  15. Article
  16. Advances in assessing body composition during pregnancy.European journal of clinical nutrition · 2018
    Review
  17. Obesity and asthma.The Journal of allergy and clinical immunology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

V T BoyleGravida, National Centre for Growth and Development and The Liggins Institute, University of Auckland, Auckland, New Zealand.
E B ThorstensenGravida, National Centre for Growth and Development and The Liggins Institute, University of Auckland, Auckland, New Zealand.
J M D ThompsonThe Department of Paediatrics, Child & Youth Health, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
L M E McCowanThe Department of Obstetrics and Gynaecology and South Auckland Clinical School, University of Auckland, Auckland, New Zealand.
E A MitchellThe Department of Paediatrics, Child & Youth Health, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
K M GodfreyMRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
L PostonDivision of Women's Health, King's College London, London, UK.
C R WallDepartment of Nutrition, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
R MurphyThe School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
W CutfieldGravida, National Centre for Growth and Development and The Liggins Institute, University of Auckland, Auckland, New Zealand.
T KenealyThe School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
L C KennyThe Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Cork, Ireland.
P N BakerGravida, National Centre for Growth and Development and The Liggins Institute, University of Auckland, Auckland, New Zealand.
University of Auckland · NZKing's College London · GBNIHR Southampton Biomedical Research Centre · GBUniversity College Cork · IEUniversity of Leicester · GB

Funding

British Heart Foundation RG/15/17/31749Medical Research Council MC_UU_12011/4
6 · The paper itself

Abstract

backgroundVitamin D insufficiency (defined as <75 nmol l SUBJECTS AND

methodsMaternal 25-hydroxyvitamin D concentrations were analysed in serum samples collected at 15 weeks' gestation from 1710 participants of the prospective Screening for Pregnancy Endpoints cohort study. The offspring of 1208 mothers were followed up at age 5-6 years. Data collected included height, weight, percentage body fat (PBF, measured by bioimpedance) and history of asthma and eczema. Multivariable analysis controlled for maternal body mass index (BMI), age and sex of the child and season of serum sampling.

resultsComplete data were available for 922 mother-child pairs. Each 10 nmol l

conclusionsThe finding of a relationship between maternal vitamin D status and adiposity in childhood is important, particularly because vitamin D insufficiency in pregnancy is highly prevalent. The association between maternal vitamin D supplementation in pregnancy and adiposity in the offspring merits examination in randomised controlled trials.

Indexed as

MothersAdiposityAdultAsthmaChild, PreschoolEczemaFemaleFollow-Up StudiesHumansInfantInfant, NewbornMaleMaternal Nutritional Physiological PhenomenaNutrition SurveysPediatric ObesityPregnancy25-hydroxyvitamin DVitamin D

Identifiers

PMID28775375
OpenAlexW2743777025

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.