ArticleScientific reports2017
A conserved neuronal DAF-16/FoxO plays an important role in conveying pheromone signals to elicit repulsion behavior in Caenorhabditis elegans.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Meloidogyne incognita genes involved in the repellent behavior in response to ascr#9.Scientific reports · 2024Article
- Chemosensory signal transduction in Caenorhabditis elegans.Genetics · 2021Review
- DMSO Delays Alzheimer Disease Causing Aβ-induced Paralysis inAnnals of neurosciences · 2021Article
- The phosphatidylinositol transfer protein PITP-1 facilitates fast recovery of eating behavior after hypoxia in the nematode Caenorhabditis elegans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- A novel functional cross-interaction between opioid and pheromone signaling may be involved in stress avoidance in Caenorhabditis elegans.Scientific reports · 2020Article
- A Molecular Basis for Reciprocal Regulation between Pheromones and Hormones in Response to Dietary Cues inInternational journal of molecular sciences · 2020Article
- Ascaroside Pheromones: Chemical Biology and Pleiotropic Neuronal Functions.International journal of molecular sciences · 2019Review
- DAF-16/FOXO promotes taste avoidance learning independently of axonal insulin-like signaling.PLoS genetics · 2019Article
- A primer on pheromone signaling in Caenorhabditis elegans for systems biologists.Current opinion in systems biology · 2019Article
- Neuropeptide Signaling Regulates Pheromone-Mediated Gene Expression of a Chemoreceptor Gene inMolecules and cells · 2019Article
- Feeding state regulates pheromone-mediated avoidance behavior via the insulin signaling pathway inThe EMBO journal · 2018Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Animals use pheromones as a conspecific chemical language to respond appropriately to environmental changes. The soil nematode Caenorhabditis elegans secretes ascaroside pheromones throughout the lifecycle, which influences entry into dauer phase in early larvae, in addition to sexual attraction and aggregation. In adult hermaphrodites, pheromone sensory signals perceived by worms usually elicit repulsion as an initial behavioral signature. However, the molecular mechanisms underlying neuronal pheromone sensory process from perception to repulsion in adult hermaphrodites remain poorly understood. Here, we show that pheromone signals perceived by GPA-3 is conveyed through glutamatergic neurotransmission in which neuronal DAF-16/FoxO plays an important modulatory role by controlling glutaminase gene expression. We further provide evidence that this modulatory role for DAF-16/FoxO seems to be conserved evolutionarily by electro-physiological study in mouse primary hippocampal neurons that are responsible for glutamatergic neurotransmission. These findings provide the basis for understanding the nematode pheromone signaling, which seems crucial for adaptation of adult hermaphrodites to changes in environmental condition for survival.
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