Evidence map›Paper›PMID 28775322›Full record

ArticleNature communications2017

Structural basis of Notch O-glucosylation and O-xylosylation by mammalian protein-O-glucosyltransferase 1 (POGLUT1).

Zhijie Li, Michael Fischer, Malathy Satkunarajah, Dongxia Zhou, Stephen G Withers, James M Rini

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Distinct O-Linked Glycosylation Systems in Signaling and Immune Regulation.International journal of molecular sciences · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. HIT-2: Implementing machine learning algorithms to treat bound ions in biomolecules.Computational and structural biotechnology journal · 2023
    Article
  9. Article
  10. Significant Roles of NotchMolecules (Basel, Switzerland) · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Current Views on the Roles ofBiomolecules · 2021
    Review
  16. Review
  17. Review
  18. Other Types of Glycosylation.Advances in experimental medicine and biology · 2021
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zhijie LiDepartment of Biochemistry, University of Toronto, Toronto, ON, Canada, M5S 1A8.ORCID http://orcid.org/0000-0001-9283-6072
Michael FischerDepartment of Chemistry, University of British Columbia, Vancouver, BC, Canada, V6T 1Z1.
Malathy SatkunarajahDepartment of Biochemistry, University of Toronto, Toronto, ON, Canada, M5S 1A8.
Dongxia ZhouDepartment of Biochemistry, University of Toronto, Toronto, ON, Canada, M5S 1A8.
Stephen G WithersDepartment of Chemistry, University of British Columbia, Vancouver, BC, Canada, V6T 1Z1.
James M RiniDepartment of Biochemistry, University of Toronto, Toronto, ON, Canada, M5S 1A8. james.rini@utoronto.ca.
University of Toronto · CAUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein O-glucosyltransferase 1/Rumi-mediated glucosylation of Notch epidermal growth factor-like (EGF-like) domains plays an important role in Notch signaling. Protein O-glucosyltransferase 1 shows specificity for folded EGF-like domains, it can only glycosylate serine residues in the C

Indexed as

Catalytic DomainGene Expression Regulation, EnzymologicGlucosyltransferasesHEK293 CellsHumansModels, MolecularProtein ConformationReceptors, NotchGlucosyltransferasesPOGLUT1 protein, humanReceptors, Notch

Identifiers

PMID28775322
PMCPMC5543122
OpenAlexW2739700872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.