Evidence map›Paper›PMID 28775151›Full record

ArticleJournal of cell science2017

The requirement of IRE1 and XBP1 in resolving physiological stress during

Huai-Wei Huang, Xiaomei Zeng, Taiyoun Rhim, David Ron, Hyung Don Ryoo

Open access · hybridAbstract read
In one paragraph

Article in Journal of cell science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Developmentally-regulated post-apocrine cell death ofFrontiers in cell and developmental biology · 2026
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  7. A genome-wide survey reveals a diverse array of enhancers coordinate thebioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Evolutionary Aspects of the Unfolded Protein Response.Cold Spring Harbor perspectives in biology · 2022
    Article
  12. Regulation of Archease by the mTOR-vATPase axis.Development (Cambridge, England) · 2022
    Article
  13. Panax notoginseng saponin reducesAnnals of translational medicine · 2022
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Drosophila Unfolded Protein Response (UPR) Assays In Vitro and In Vivo.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  19. Heat Stress-Mediated Constraints in Maize (Frontiers in plant science · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

Huai-Wei HuangDepartment of Cell Biology, New York University School of Medicine, New York 10016, USA.
Xiaomei ZengKey Laboratory of Molecular Biophysics of Ministry of Education, Center for Human Genome Research, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430000, China.
Taiyoun RhimDepartment of Bioengineering, Hanyang University, Seoul 04763, Korea.
David RonDepartment of Clinical Biochemistry, Cambridge Institute for Medical Research, Cambridge CB2 0XY, UK.
Hyung Don RyooDepartment of Cell Biology, New York University School of Medicine, New York 10016, USA hyungdon.ryoo@nyumc.org.ORCID http://orcid.org/0000-0002-1046-535X
New York University · USHanyang University · KRHuazhong University of Science and Technology · CNNational Institute for Health Research · GB

Funding

Unfolded Protein Response in Eye Development and DiseaseR01EY020866 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HYUNG D RYOO · 2010 to 2026
$6.9M
NEI NIH HHS R01 EY020866Wellcome Trust 200848/Z/16/Z
6 · The paper itself

Abstract

IRE1 mediates the unfolded protein response (UPR) in part by regulating XBP1 mRNA splicing in response to endoplasmic reticulum (ER) stress. In cultured metazoan cells, IRE1 also exhibits XBP1-independent biochemical activities. IRE1 and XBP1 are developmentally essential genes in

Indexed as

Stress, PhysiologicalAnimalsDNA-Binding ProteinsDown-RegulationDrosophila melanogasterDrosophila ProteinsEndoribonucleasesGastrointestinal TractGene Expression Regulation, DevelopmentalGene OntologyImmunity, InnateLarvaMaleMutationTransgenesUp-RegulationDNA-Binding ProteinsDrosophila ProteinsEndoribonucleasesinositol requiring enzyme-1, DrosophilaXbp1 protein, DrosophilaAccessory glandEjaculatory ductGastric caecaIre1Male sterilityMidgutPhysiological ER stressProventriculusUnfolded protein responseXbp1

Identifiers

PMID28775151
PMCPMC5612175
OpenAlexW2742532139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.