ArticleOccupational and environmental medicine2018
Occupational pesticide exposure and subclinical hypothyroidism among male pesticide applicators.
Article in Occupational and environmental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Exposure to pesticides and the risk of hypothyroidism: a systematic review and meta-analysis.BMC public health · 2023Pooled it
- Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Endocrine-Disrupting Pesticides as Drivers of Human Disease: Mechanistic Toxicology and Life-Course Health Effects.International journal of molecular sciences · 2026Review
- Associations between persistent organic pollutants and thyroid-related hormones and homeostasis parameters in middle-aged to older men and postmenopausal women: The HCHS/SOL.Environmental research · 2025Article
- What Is the Impact of Glyphosate on the Thyroid? An Updated Review.Biomedicines · 2025Review
- Carbaryl use and incident cancer in the Agricultural Health Study: an updated analysis.International journal of hygiene and environmental health · 2025Article
- Cross-Sectional Examination of Thyroid Hormones and Environmental Exposure to Multiclass Pesticides in Women of Reproductive Age in China.Environmental health perspectives · 2024Article
- Sex-specific transgenerational effects on murine thyroid gland imposed by ancestral exposure to neonicotinoid thiacloprid.Scientific reports · 2024Article
- Contributions of Synthetic Chemicals to Autoimmune Disease Development and Occurrence.Current environmental health reports · 2024Review
- Specific effects on the thyroid relevant for performing a dietary cumulative risk assessment of pesticide residues: 2024 update.EFSA journal. European Food Safety Authority · 2024Article
- Review
- Article
- Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs).Toxicology reports · 2021Review
- Pesticide exposure and incident thyroid cancer among male pesticide applicators in agricultural health study.Environment international · 2021Article
- Article
- Genetic Polymorphisms of Pesticide-Metabolizing Enzymes and Transporters in Agricultural Workers and Thyroid Hormone Levels.Risk management and healthcare policy · 2021Article
- Synthetic Pesticides and Health in Vulnerable Populations: Agricultural Workers.Current environmental health reports · 2020Review
- Is the Observed Decrease in Body Temperature During Industrialization Due to Thyroid Hormone-Dependent Thermoregulation Disruption?Frontiers in endocrinology · 2020Article
- Establishment of cumulative assessment groups of pesticides for their effects on the thyroid.EFSA journal. European Food Safety Authority · 2019Article
- Thyroid Hormones in Conventional and Organic Farmers in Thailand.International journal of environmental research and public health · 2019Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
Abstract
objectivesAnimal studies suggest that exposure to pesticides may alter thyroid function; however, few epidemiologic studies have examined this association. We evaluated the relationship between individual pesticides and thyroid function in 679 men enrolled in a substudy of the Agricultural Health Study, a cohort of licensed pesticide applicators.
methodsSelf-reported lifetime pesticide use was obtained at cohort enrolment (1993-1997). Intensity-weighted lifetime days were computed for 33 pesticides, which adjusts cumulative days of pesticide use for factors that modify exposure (eg, use of personal protective equipment). Thyroid-stimulating hormone (TSH), thyroxine (T4), triiodothyronine (T3) and antithyroid peroxidase (anti-TPO) autoantibodies were measured in serum collected in 2010-2013. We used multivariate logistic regression to estimate ORs and 95% CIs for subclinical hypothyroidism (TSH >4.5 mIU/L) compared with normal TSH (0.4-
resultsHigher exposure to the insecticide aldrin (third and fourth quartiles of intensity-weighted days vs no exposure) was positively associated with subclinical hypothyroidism (OR
conclusionsOur results suggest that long-term exposure to aldrin, pendimethalin and methyl bromide may alter thyroid function among male pesticide applicators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.