ArticleJournal of the American Heart Association2017
Ectopy on a Single 12-Lead ECG, Incident Cardiac Myopathy, and Death in the Community.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Frequent premature ventricular complexes and risk of atrial fibrillation, heart failure, stroke and mortality: a meta-analysis.Heart (British Cardiac Society) · 2025Pooled it
- Excessive Supraventricular Ectopic Activity and Adverse Cardiovascular Outcomes: a Systematic Review and Meta-analysis.Current atherosclerosis reports · 2020Pooled it
- Association of blood pressure control with atrial and ventricular ectopy in SPRINT.Open heart · 2025Trial
- Premature Atrial Contractions as a Marker of Atrial Cardiopathy: A Revised Analysis of the ARCADIA Randomized Trial.Journal of cardiovascular electrophysiology · 2025Trial
- Acute Effects of Coffee Consumption on Health among Ambulatory Adults.The New England journal of medicine · 2023Trial
- Determinants and prognostic value of atrial and ventricular ectopic burden in adults without structural heart disease.European heart journal open · 2026Article
- Systemic Inflammation Is Associated with Resting Premature Atrial and Ventricular Contractions in American Older Adults.The Journal of innovations in cardiac rhythm management · 2026Article
- Specific Premature Ventricular Complex Characteristics in Women: Insights from a Patient Cohort.Journal of cardiovascular development and disease · 2025Article
- Shorter Premature Atrial Complex Coupling Interval Leads to Mechanical Dysfunction, Fibrosis, and AF in Swine.JACC. Clinical electrophysiology · 2025Article
- Predictors of Myocardial Fibrosis Detected by CMR in Patients With Idiopathic PVCs.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2024Article
- Classification of Premature Ventricular Contractions in Athletes During Routine Preparticipation Exams.Circulation. Arrhythmia and electrophysiology · 2024Article
- Article
- Role of Cardiac Magnetic Resonance in the Assessment of Patients with Premature Ventricular Contractions: A Narrative Review.Anatolian journal of cardiology · 2024Article
- Longitudinal association of premature atrial contractions with atrial fibrillation and brain ischemia in people with type 2 diabetes: The Hoorn Diabetes Care System cohort.American heart journal plus : cardiology research and practice · 2023Article
- Premature atrial and ventricular contractions detected on wearable-format electrocardiograms and prediction of cardiovascular events.European heart journal. Digital health · 2023Article
- Excessive Supraventricular Ectopic Activity and the Risk of Atrial Fibrillation and Stroke: A Systematic Review and Meta-Analysis.Journal of cardiovascular development and disease · 2022Review
- Arrhythmias as Presentation of Genetic Cardiomyopathy.Circulation research · 2022Review
- Unique Cardiovascular Disease Risk Factors in Hispanic Individuals.Current cardiovascular risk reports · 2022Review
- Associations of Left Atrial Function and Structure With Supraventricular Ectopy: The Multi-Ethnic Study of Atherosclerosis.Journal of the American Heart Association · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundAtrial fibrillation and heart failure are 2 of the most common diseases, yet ready means to identify individuals at risk are lacking. The 12-lead ECG is one of the most accessible tests in medicine. Our objective was to determine whether a premature atrial contraction observed on a standard 12-lead ECG would predict atrial fibrillation and mortality and whether a premature ventricular contraction would predict heart failure and mortality. METHODS AND
resultsWe utilized the CHS (Cardiovascular Health) Study, which followed 5577 participants for a median of 12 years, as the primary cohort. The ARIC (Atherosclerosis Risk in Communities Study), the replication cohort, captured data from 15 792 participants over a median of 22 years. In the CHS, multivariable analyses revealed that a baseline 12-lead ECG premature atrial contraction predicted a 60% increased risk of atrial fibrillation (hazard ratio, 1.6; 95% CI, 1.3-2.0;
conclusionsBased on a single standard ECG, a premature atrial contraction predicted incident atrial fibrillation and death and a premature ventricular contraction predicted incident heart failure and death, suggesting that this commonly used test may predict future disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.