Trial reportAJNR. American journal of neuroradiology2017
In Vivo Imaging of Venous Side Cerebral Small-Vessel Disease in Older Adults: An MRI Method at 7T.
Trial report in AJNR. American journal of neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
- Effect of vitamin D3 supplementation on vascular and metabolic health of vitamin D-deficient overweight and obese children: a randomized clinical trial.The American journal of clinical nutrition · 2020Trial
- Physical Activity and Cerebral Small Vein Integrity in Older Adults.Medicine and science in sports and exercise · 2019Trial
- Retinal microvascular dysfunction in mild cognitive impairment: Associations with cerebral small vessel disease, plasma biomarkers, and cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Deep learning retinal imaging model identifies poor brain health among older adults without dementia.Cerebral circulation - cognition and behavior · 2026Article
- Intracranial arterial calcification and cerebrovascular function in the general aging population - A 7T MRI Study.Cerebral circulation - cognition and behavior · 2026Article
- Article
- Arterial and venous flow dynamics are modified by age in the non-human primate.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Brain endothelial cell activation and dysfunction associate with and contribute to the development of enlarged perivascular spaces and cerebral small vessel disease.Histology and histopathology · 2024Review
- Report from the society of magnetic resonance angiography: clinical applications of 7T neurovascular MR in the assessment of intracranial vascular disease.Journal of neurointerventional surgery · 2024Review
- VICTR: Venous transit time imaging by changes in TMagnetic resonance in medicine · 2024Article
- Advancements in investigating the role of cerebral small vein loss in Alzheimer's disease-related pathological changes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Cerebral venous congestion alters brain metabolite profiles, impairing cognitive function.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Article
- The Venular Side of Cerebral Amyloid Angiopathy: Proof of Concept of a Neglected Issue.Biomedicines · 2023Review
- Exploring the Impact of Age of Onset of Mild Cognitive Impairment on the Profile of Cognitive and Psychiatric Symptoms.Geriatrics (Basel, Switzerland) · 2023Article
- Exploration of the correlation between superficial cerebral veins identified using susceptibility-weighted imaging findings and cognitive differences between sexes based on deep learning: a preliminary study.Quantitative imaging in medicine and surgery · 2023Article
- Seven Tesla MRI in Alzheimer's disease research: State of the art and future directions: A narrative review.AIMS neuroscience · 2023Review
- Association of deep medullary veins with the neuroimaging burden of cerebral small vessel disease.Quantitative imaging in medicine and surgery · 2023Article
- Cerebral Venous Reflux and Dilated Basal Ganglia Perivascular Space in Hypertensive Intracerebral Hemorrhage.Journal of stroke · 2022Article
- Leukoaraiosis is associated with clinical symptom severity, poor neurological function prognosis and stroke recurrence in mild intracerebral hemorrhage: a prospective multi-center cohort study.Neural regeneration research · 2022Article
Corrections and comments
- Erratum issuedErratum.2018
Authors and funding
15 authors at 9 institutions in 6 countries.
Funding
Abstract
background and purposeTraditional neuroimaging markers of small-vessel disease focus on late-stage changes. We aimed to adapt a method of venular assessment at 7T for use in older adults. We hypothesized that poorer venular morphologic characteristics would be related to other small-vessel disease neuroimaging markers and a higher prevalence of small-vessel disease-Alzheimer disease risk factors. MATERIALS AND
methodsVenules were identified in periventricular ROIs on SWI and defined as tortuous or straight. The tortuosity ratio was defined as total tortuous venular length divided by total straight venular length. White matter hyperintensity burden (visually rated from 0 to 3) and the number of microbleeds (0, 1, >1) were determined. Differences in tortuous and straight venular lengths were evaluated. Relationships with demographic variables, allele producing the e4 type of
resultsParticipants had 42% more tortuous venular tissue than straight (median, 1.42; 95% CI, 1.13-1.62).
conclusionsMorphologic measures of venules at 7T could be useful biomarkers of the early stages of small-vessel disease and Alzheimer disease. Longitudinal studies should examine the impact of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.