Evidence map›Paper›PMID 28775001›Full record

ArticleJournal of the American Society of Nephrology : JASN2017

Characterization and Correction of Olfactory Deficits in Kidney Disease.

Sagar U Nigwekar, Jeremy M Weiser, Sahir Kalim, Dihua Xu, Joshua L Wibecan, Sarah M Dougherty, Laurence Mercier-Lafond, Kristin M Corapi, Nwamaka D Eneanya, Eric H Holbrook and 3 more

2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04789499 phase2completednot on this mapstarted 2021, after this paper: background citation

Smell in Covid-19 and Efficacy of Nasal Theophylline

TypeinterventionalSponsorWashington University School of MedicineRan2021 to 2021Enrolled51ConditionsCovid19, Anosmia, Olfactory Disorder, Covid-19 PandemicArmsTheophylline Powder, Placebo Comparator
NCT06498687 phase1withdrawnnot on this mapstarted 2025, after this paper: background citation

A Single-Arm Study to Evaluate the Feasibility of CYR-064 Theophylline Nasal Spray for the Treatment of Parkinson's Disease Related Hyposmia and Anosmia

TypeinterventionalSponsorUniversity of NebraskaRan2025 to 2026Enrolled0ConditionsHyposmia, AnosmiaArmsCYR-064
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Olfactory function in diabetes mellitus.Journal of clinical & translational endocrinology · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. International consensus statement on allergy and rhinology: Olfaction.International forum of allergy & rhinology · 2022
    Review
  12. Therapies for Olfactory Dysfunction - an Update.Current allergy and asthma reports · 2022
    Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Anosmia: A review in the context of coronavirus disease 2019 and orofacial pain.Journal of the American Dental Association (1939) · 2020
    Review
  18. Otorhinolaryngological dysfunctions induced by chronic kidney disease in pre- and post-transplant stages.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Sagar U NigwekarDivision of Nephrology, Department of Medicine, and Paunescu.Teodor@mgh.harvard.edu snigwekar@mgh.harvard.edu.
Jeremy M WeiserDivision of Nephrology, Department of Medicine, and.
Sahir KalimDivision of Nephrology, Department of Medicine, and.
Dihua XuDivision of Nephrology, Department of Medicine, and.
Joshua L WibecanDivision of Nephrology, Department of Medicine, and.
Sarah M DoughertyDivision of Nephrology, Department of Medicine, and.
Laurence Mercier-LafondDivision of Nephrology, Department of Medicine, and.
Kristin M CorapiDivision of Nephrology, Department of Medicine, and.
Nwamaka D EneanyaDivision of Nephrology, Department of Medicine, and.
Eric H HolbrookHarvard Medical School, Boston, Massachusetts; and.
Dennis BrownDivision of Nephrology, Department of Medicine, and.
Ravi I ThadhaniDivision of Nephrology, Department of Medicine, and.
Teodor G PăunescuDivision of Nephrology, Department of Medicine, and Paunescu.Teodor@mgh.harvard.edu snigwekar@mgh.harvard.edu.
Harvard University · USCenter for Systems Biology · USMassachusetts Eye and Ear Infirmary · USMassachusetts General Hospital · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
The effects of protein carbamylation in end stage kidney diseaseK23DK106479 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KALIM, SAHIR · 2015 to 2019
$789k
NCATS NIH HHS UL1 TR001102NIDDK NIH HHS K23 DK106479
6 · The paper itself

Abstract

Patients with CKD suffer from food aversion, anorexia, and malnutrition. Although olfaction has a significant role in determining food flavor, our understanding of olfactory impairment and of the olfaction-nutrition axis in patients with kidney disease is limited. We quantified odor identification, odor threshold, and subjective odor perception in a cohort (

Indexed as

FemaleHumansKidney Failure, ChronicMaleMiddle AgedOlfaction DisordersPhosphodiesterase InhibitorsRenal Insufficiency, ChronicTheophyllinePhosphodiesterase InhibitorsTheophyllinechronic kidney diseaseend-stage renal diseasemalnutritionolfactiontheophylline

Identifiers

PMID28775001
PMCPMC5661283
OpenAlexW2743098933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.