Evidence map›Paper›PMID 28775000›Full record

ArticleJournal of the American Society of Nephrology : JASN2017

BPI Fold-Containing Family A Member 2/Parotid Secretory Protein Is an Early Biomarker of AKI.

Satya K Kota, Elizabeth Pernicone, David E Leaf, Isaac E Stillman, Sushrut S Waikar, Savithri Balasubramanian Kota

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

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  10. Review
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  13. Review
  14. BPIFA2 as a Novel Early Biomarker to Identify Fatal Radiation Injury After Radiation Exposure.Dose-response : a publication of International Hormesis Society
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Satya K KotaDepartment of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Harvard University, Boston, Massachusetts.
Elizabeth PerniconeDivision of Nephrology, Department of Medicine and.
David E LeafDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Isaac E StillmanDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; and.
Sushrut S WaikarDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Savithri Balasubramanian KotaHarvard Stem Cell Institute, Cambridge, Massachusetts; skota@bidmc.harvard.edu.
Harvard University · US

Funding

Urinary Biomarkers of Chronic Kidney Disease Pathology and ProgressionU01DK085660 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT, WAIKAR, SUSHRUT S. · 2009 to 2019
$5.3M
Biomarkers of Kidney PathologyR01DK093574 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI WAIKAR, SUSHRUT S. · 2012 to 2015
$2.4M
Novel Human Biomarkers of Kidney FibrosisU01DK104308 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HUMPHREYS, BENJAMIN D., WAIKAR, SUSHRUT S. · 2014 to 2018
$2.0M
Oxalate and the Progression and Complications of CKDR01DK103784 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI WAIKAR, SUSHRUT S. · 2015 to 2018
$1.6M
Dysregulated Mineral Metabolism and Acute Kidney InjuryK23DK106448 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI LEAF, DAVID EVAN · 2015 to 2019
$964k
Epigenetic regulation of skeletal patterning and morphogenesis during developmentK01AR069197 · NIAMS · HARVARD MEDICAL SCHOOL · PI KOTA, SATYA K. · 2016 to 2020
$563k
Retinoid mediated protection against AKI during agingR21AG047412 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KOTA, SAVITHRI BALASUBRAMANIAN · 2015 to 2016
$479k
NIAMS NIH HHS K01 AR069197NIA NIH HHS R21 AG047412NIDDK NIH HHS K23 DK106448NIDDK NIH HHS R01 DK093574NIDDK NIH HHS R01 DK103784NIDDK NIH HHS U01 DK085660NIDDK NIH HHS U01 DK104308
6 · The paper itself

Abstract

AKI is a major cause of morbidity and mortality and an important contributor to the development and progression of CKD. Molecular biomarkers that improve the detection and prognostication of AKI are therefore required. We assessed the utility as such of BPI fold-containing family A member 2 (BPIFA2), also known as parotid secretory protein, which we identified

Indexed as

Acute Kidney InjuryAnimalsBiomarkersDisease ProgressionGene Expression ProfilingGene Expression RegulationHumansKidneyMaleMiceMicroscopy, FluorescenceNuclear Receptor Subfamily 4, Group A, Member 1Parotid GlandPromoter Regions, GeneticProtein FoldingProteomicsBiomarkersBpifa2 protein, mouseNr4a1 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 1Salivary Proteins and Peptidesischemia-reperfusionrenal injuryrenal ischemia

Identifiers

PMID28775000
PMCPMC5698064
OpenAlexW2744439428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.